肝非可控性炎症与肝癌的相关性研究

Study on the Relationship Between Non Controllable Liver Inflammation and Liver Cancer

目的:应用炎症因子与肿瘤指标联合检测找出乙肝患者肝癌转化的相关性。方法:选取2014年3月-2016年6月笔者所在科室诊治的患者160例,分为原发性肝细胞癌伴HBV阳性组,原发性肝细胞癌且HBV阴性组,健康组,无肝癌症状HBV携带组,分离患者血清,检测血清中ALT、AST、IL-2、IL-6。结果:原发性肝癌伴HBV(+)组ALT、AST、IL-2水平最高,原发性肝癌伴HBV(-)组次之,无肝癌症状HBV携带组再次之,健康组最低。无肝癌症状HBV(+)组与健康组比较差异无统计学意义(P>0.05);其余各组比较差异均有统计学意义(P<0.05)。血清IL-6的表达水平则为原发性肝癌伴HBV(+)组最高,原发性肝癌伴HBV(-)组次之,无症状HBV(+)组再次之,健康组最低,各组间比较差异均有统计学意义(P<0.05)。结论:IL-2与IL-6结合AST、ALT诊断可提高肝癌的诊出率。

Objective:To explore the transformation of hepatocellular carcinoma in patients with hepatitis B and inflammatory factors and tumor markers.Method: 160 cases who were made a diagnosis and given treatment in the department from March 2014 to June 2016 were selected,and divided into primary hepatocellular carcinoma with HBV(+) group,primary hepatocellular carcinoma with HBV(-) group,healthy group,no symptoms of liver cancer group,asymptomatic HBV carrier group,and serum ALT,AST,IL-2,IL-6 were detected.Result:The ALT,AST and IL-2 levels of Primary liver cancer with HBV(+) group were the highest,then primary liver cancer with HBV(-) group and asymptomatic HBV(+) group followed,while health group was the lowest.There was no significant difference between the HBV(+) group and healthy group(P>0.05).And there were significant differences between the others(P<0.05).The average expression level of serum IL-6 in primary liver cancer with HBV(+) group was the highest,then primary liver cancer with HBV(-) group and asymptomatic HBV(+) group followed,while health group was the lowest.Conclusion:Combining the IL-2 and IL-6 with AST and ALT can bring a high diagnostic rate of liver cancer.