心理压力与男性精液质量相关性Meta分析

Association between psychological stress and male semen quality:a Meta-analysis

目的评价心理因素与精液质量的相关性。方法采用Meta分析的方法,利用网络数据库检索Cochrane Library、Pubmed、Medline、Springerlink、中国生物医学文献数据库(CMB)、中国知网全文数据库(CNKI)和万方数据库,查找关于心理因素与精液质量相关的研究,按照纳入、排除标准对文献进行筛选、资料提取和质量评价后,由R语言对数据进行统计学处理。结果共纳入13篇研究,总样本量为4 936例。Meta分析结果显示:心理压力与男性精子总数、精子浓度、a+b级精子呈显著负相关(r=-0.312,r=-0.317,r=-0.486,P<0.001),心理压力与a级精子呈负相关(r=-0.545,P=0.028),心理压力与精子形态无相关性(r=-0.218,P=0.117)。亚组分析结果显示,2010年至今较1999—2009年,男性的心理压力与精液质量相关性更大。结论心理压力与男性精液质量呈负相关。重视男性的心理健康将有助于其生殖健康。

Objective To evaluate the correlation between psychological stress and semen quality by Meta-analysis. Methods Cochrane Library, Pubmed, Medline, Springerlink, Chinese Biomedical Literature Database （CMB）, CNKI and Wanfang Database were searched by network database to find out the relationship between psychological stress and semen quality. The included studies were screened according to the inclusion and exclusion criteria. After data extraction and quality evaluation, the data were statistically processed by R language. Results Thirteen studies were included, with a total sample size of 4 936 patients. The results of Meta-analysis showed that the psychological stress was significantly negative correlated with sperm count （r=-0.312）, sperm density （r = -0.327） and progress motility （r = -0.496, P〈0.001）. The psychologica stress was negatively correlated with rapid progress motility （r =-0.545, P=0.028）, and psychological stress had no correlation with sperm morphology （r = -0.218, P=0.117）. Subgroup analysis showed that the association between psychological stress and male semen quality was greater in 2010 to now than in 1999 to 2009. Conclusion The psychological stress is negatively related to the semen quality of male. Attention to men＇s psychological health will contribute to their reproductive health.