左旋多巴联合综合疗法治疗青少年屈光不正性弱视的临床疗效研究

Study on Clinical Effect of Levodopa Combined with Comprehensive Therapy in the Treatment of Adolescent Ametropic Amblyopia

目的探讨左旋多巴联合综合疗法治疗青少年屈光不正性弱视的临床疗效。方法选取我院2014年12月至2016年3月收治的136例(214眼)青少年屈光不正性弱视患者,随机分为研究组(68例,104眼)和对照组(68例,110眼)。对照组采用综合疗法,研究组在对照组基础上加服左旋多巴。对比两组患者的治疗效果。结果研究组的总有效率为86.54%,明显高于对照组的62.73%,差异有统计学意义(P<0.05)。研究组的P-VEP P100振幅明显高于对照组,潜伏期短于对照组,差异有统计学意义(P<0.05)。研究组的矫正分开范围和矫正辐辏范围均大于对照组,差异有统计学意义(P<0.05)。研究组的矫正近立体视锐度小于对照组,差异有统计学意义(P<0.05)。结论左旋多巴联合综合疗法对青少年屈光不正性弱视的治疗效果优于单纯采用综合疗法,值得临床推广应用。

Objective To explore the clinical effect of levodopa combined with comprehensive therapy in the treatment of adolescent ametropic amblyopia. Methods 136 cases （214 eyes） of patients with adolescent ametropic amblyopia admitted to our hospital from December 2014 to March 2016 were selected and randomly divided into study group （68 cases, 104 eyes） and control group （68 cases, 110 eyes）. The control group received comprehensive therapy, while the study group received levodopa on the basis of control group. The treatment effect of patients was compared between two groups. Results The total effective rate of study group was 86.54%, significantly higher than 62.73% of control group, with statistical difference （P 〈0.05）. The amplitude of P-VEP P100 of study group was significantly higher than that of control group, and the incubation period was shorter than that of control group, with statistical differences （P 〈0.05）. The corrected separation range and corrected convergence range were larger than those of control group, with statistical differences （P 〈0.05）. The corrected near distance stereoacuity was smaller than that of control group, with statistical difference （P〈0.05）. Conclusions Compared with pure comprehensive therapy, levodopa combined with comprehensive therapy in the treatment of adolescent ametropia amblyopia has better treatment effect, which is worthy of clinical promotion and application.