阿那曲唑和依西美坦在新辅助内分泌治疗老年乳腺癌中的临床研究

Clinical study of anastrozole and exemestane in neoadjuvant endocrine therapy for elderly breast cancer

目的:探讨阿那曲唑、依西美坦在新辅助内分泌治疗老年乳腺癌中的临床效果。方法:选择2010年1月至2015年6月本院收治的老年乳腺癌患者80例,按照随机数字法分为两组,各40例,对照组使用依西美坦,观察组使用阿那曲唑片,比较两组治疗后临床效果及治疗过程中发生的不良反应。结果:观察组治疗后有效率为72.5%,显著高于对照组的47.5%,χ~2=5.208,P=0.022<0.05;观察组发生面部潮红、癌性乏力、骨关节痛及食欲减退的比例显著低于对照组(P<0.05)。结论:使用阿那曲唑新辅助内分泌治疗老年乳腺癌患者,能有效改善患者临床治疗效果,且治疗过程中不良反应少,值得临床重视。

Objective.. To investigate the clinical value of anastrozole vs exemestane of neoadjuvant endocrine therapy in elderly breast cancer. Methods： 80 cases with elderly patients with breast cancer from January 2013 to June 2014 in our hospital ran- domly divided into two groups, each 40 patients, the control group were used exemestane, the observation group were used anastrozole, then the clinical efficacy and adverse events during treatment were compared. Results： The effective rate in the ob- servation group was 72.5% ,it was significantly higher than the 47. 5% of control group （χ2=5. 208, P=0. 022〈0. 05）, observation group had facial flushing, cancer fatigue, bone and joint pain and loss of appetite significant proportion was lower than control group （P 〈 0. 05）. Conclusion.- Anastrozole neoadjuvant endocrine therapy in elderly breast cancer patients can effectively improve the clinical treatment of patients, and fewer adverse reactions during treatment, worthy of attention.