危重患儿并发系统性炎症反应综合征调控机制的研究进展

Research progress on pathogenesis of systemic inflammatory response syndrome in critical illness children

系统性炎症反应综合征是危重患儿的一种病理生理状态,发病机制涉及免疫功能紊乱、基因调控及肠黏膜屏障功能障碍等多个环节.通过研究系统性炎症反应综合征的调控机制,可以对系统性炎症反应综合征做出早期诊断.根据机体炎症反应状态,针对发病机制的各个环节,采取综合治疗措施,从而阻止全身炎症反应的进一步发展,改善危重患儿的预后.

Systemic inflammatory response syndrome （SIRS） is a pathophysiological process of critical children.It＇s pathogenesis involved many sides such as immune dysfunction,gene expression regulation and intestinal barrier.By studying the regulation mechanism of SIRS,early diagnosis of SIRS can be made.According to the inflammatory status and each sides of pathogenesis,effective control results can be taken in time to stop the further developmentof SIRS and improve outcomes of critical children.