硫酸化黑木耳多糖的辐射防护作用研究

Radioprotection Effects of Sulfated Auricularia auricular Polysaccharides

为考察硫酸化黑木耳多糖对^(60)Co-γ射线辐射损伤小鼠的防护作用。以硫酸化黑木耳多糖为受试物,用^(60)Co-γ射线对小鼠进行一次性全身辐射,对小鼠的免疫指标,血清中SOD活力、MDA含量,骨髓DNA含量和骨髓微核率进行测定。结果表明:硫酸化黑木耳多糖对^(60)Co-γ射线辐射损伤小鼠的单核细胞吞噬能力、血清SOD活性有明显的促进作用,并且能够增加小鼠免疫器官指数和骨髓DNA含量,减少血清MDA含量和骨髓微核率,减轻辐射诱导机体的氧化损伤。结论证实,硫酸化黑木耳多糖对^(60)Co-γ射线辐射损伤小鼠具有良好的防护作用。

In order to investigate the protective effect of sulfated A uricularia auricular polysaceharides on injured mice induced by ^60Co-γ. Sulfated A uricularia auricular polysaccharides were orally administered to groups of mice. After being exposed wholely to ^60Co-γ,immune parameters, SOD and MDA in serum , DNA and micronuclear rates in marrow were examined. Results showed that sulfated A uricularia auricular polysaccharides could increase the phagocytosis ability of monocyte and SOD activity in serum, decrease the formation of micronuclei in bone marrow and MDA in serum and reduce the oxidative damage of body induced by radiation. The conclusion of this experiment verified the fact that sulfated A uric ularia auricular polysaccharides has protective effect on damaged male induced by ^60Co-γ.