一种具有自愈合性能的多孔水凝胶的研制

Preparation of a porous hydrogel with self-healing performance

基于双网络结构的机制,通过在聚谷氨酸的侧基上接枝多巴胺构建相邻高分子链段间的弱键相互作用,再将接枝产物与聚赖氨酸通过酰胺反应制备了具有一定强度和良好自愈合性能的水凝胶。通过红外光谱及核磁共振氢谱对制备过程中的酰胺反应以及用扫描电镜对水凝胶多孔结构进行了表征;通过力学测试和黏弹性测试对水凝胶的力学性能、黏弹性及自愈合性能进行了表征;借助L929细胞共培养考察材料的生物相容性。结果表明制得的水凝胶具有一定的力学强度以及较好的孔隙结构、自愈合性能和生物相容性。

Based on the double network structure mechanism, the hydrogel with certain strength aria good self- healing performance was prepared by grafting the dopamine to the lateral group of polyglutamic acid to build the weak bond interaction between adjacent high molecular segments, then reacting the grafting product witti polylysine via the amide reaction. The amide reaction in said preparation process was characterized by using infrared spectrum and nuclear magnetic resonance hydrogen spectrum, and the hydrogel porous structure was characterized by using scanning electron microscopy. The mechanical performance, viscoelasticity and self-healing performance of the hydrogel were characterized by mechanical testing and viscoelasticity testing. The bio-compatibility of the materials was investigated by co-cultured L929 cells. The results show that the prepared hydrogel possesses certain mechanical strength and good porous structure, self-healing performance and bio-compatibility.