寒潮诱发卒中：来自易卒中型高血压大鼠研究的证据

Cold wave-induced stroke： the evidence from studies in stroke-prone hypertensive rats

流行病学资料、临床观察以及动物实验均表明寒潮与卒中发病密切相关。当具有卒中病因或危险因素的人群处于卒中前状态时，可在各种诱发因素的作用下发生卒中。寒潮作为导致机体进入卒中前状态的外部因素，存在多种可能的机制。在寒潮前1周给予易卒中型高血压大鼠药物干预可减少寒潮期卒中的发生，提示在寒潮前对卒中前状态人群进行预防性干预具有重要意义。

Epidemiological data, clinical observation and animal experiments have shown that cold wave is closely associated with the onset of stroke. When a population with stroke etiology or risk factors is under pre-stroke state, they will have stroke under the influence of various inducing factors. Cold wave is the external factor that causes the body to enter the pre-stroke state and there are many possible mechanisms. The drug intervention of stroke-prone hypertensive rats at 1 week before the cold wave can reduce the occurrence of stroke during cold wave, suggesting that it is of great significance to conduct preventive intervention to the pre-stroke population before the cold wave coming.