血脑屏障完整性与脑小血管病

Blood-brain barrier integrity and cerebral small vessel disease

脑小血管病（cerebral small vessel disease，CSVD）是一组累及小动脉、微动脉、小静脉、微静脉及毛细血管的小血管病变，影像学表现为腔隙性梗死、脑微出血、脑白质病变、血管周围间隙扩大等。近年来，CSVD发病率日益增高，给家庭和社会带来不同程度的经济负担，成为目前的研究热点。血脑屏障（blood—brain barrier，BBB）通透性改变是CSVD发病的主要原因，文章对BBB完整性与CSVD的关系进行综述。

Cerebral small vessel disease （CVSD） is a group of small vascular diseases involving small arteries, arterioles, small veins, venules, and capillaries. The imaging findings were lactmar infarction, cerebral microbleeds, cerebral white matter lesions, and perivascular space expansion. In recent years, the incidence of CSVD is increasing, which brings different degree of economic burden to the families and society. It becomes the focus of research at present. The permeability change of blood-brain barrier is the main reason for the onset of CSVD. This article reviews the relationship between the integrity of blood-brain barrier and CSVD.