药动学-药效学模型在临床合理用药的应用价值分析

Value of pharmacokinetics-pharmacodynamics model in rational drug use

药动学-药效学(pharmacokinetics-pharmacodynamics,PK-PD)结合模型阐明了时间-药物浓度-效应三者间关系,能较全面地分析和预测特定给药方案下,药物效应随时间的变化情况,对新药研发,药物临床试验及临床合理用药具有重要的参考价值。现从给药方案优化,疗效和不良反应预测,相互作用分析等方面对近年来国内外PK-PD指导临床用药情况进行综述,阐明PK-PD模型对药物合理使用的意义。

Pharmacokinetics-pharmacodynamics（PK-PD）combined model explained the relationship of time-effect-drug concentration in mathematical formula,which could comprehensively analyze and predict a time-response relationship in a certain dosage regimen.PK-PD model valued crucially in drug discovery,clinical trails and rational drug use.This paper analyzed the significance of PK-PD model in medication at home and abroad in recent years,concluding dosage regimen optimizing,predicting efficacy or adverse reactions and drug interactions.More importantly,the value of PK-PD model in rational drug use was well demonstrated.