载药再生细菌纤维素纤维的制备及其表征

Preparation and characterization of drug-loaded regenerated bacterial cellulose fiber

为获得一种具有优良生物相容性,能够用于伤口敷料的纤维材料,以细菌纤维素为原料,以氯化锂/二甲基乙酰胺为溶剂体系制备纺丝液,以水为凝固浴,采用湿法纺丝技术制备再生细菌纤维素纤维,进而以环丙沙星为模型药物对再生细菌纤维素纤维进行载药整理,制得一种可用于伤口敷料的载药纤维。通过X射线衍射、力学性能、载药性、释药性等测试对再生细菌纤维素纤维进行表征。结果表明:纤维直径约为40μm,表面呈沟槽结构,力学强度可达2.5 c N/dtex;细菌纤维素再生后,晶型发生了改变,从纤维素Ⅰ型转化成纤维素Ⅱ型,且结晶度从66.3%降低至36.2%;载药和释药结果显示,再生细菌纤维素纤维在碱性条件下载药量最高,载药纤维在酸性条件下释药量最高。

The regenerated bacterial cellulose（RBC）fiber used for wound dressing and having good biocompatibility was prepared by a wet spinning process,taking bacterial cellulose as raw material, adopting LiCl/Dimethylacetamide as solvent system and using water as coagulation bath. Then ciprofloxacin was used as model drug to prepare drug-loaded RBC fiber. The characterization of morphological, mechanical properties, XRD, drug loading and release performance were determined. The results shows that the RBC fiber had a groove surface structure with a diameter of about 40 μm. The tensile breaking strength of the RBC fiber is as high as 2.5 cN/dtex. X-ray diffraction results indicated that the crystal form of RBC fiber is transformed from cellulose crystalⅠto Ⅱ, and the degree of crystallinity is reduced from 66.3% to 36.2%. The drug loading and release experiments show that the RBC fiber had the highest drug loading capacity under alkaline condition, while the drug loaded RBC fiber has the largest release amount under acid condition.