艾滋病合并胶质瘤2例报告及文献复习

Glioblastoma in patient with AIDS: two cases report and review of literatures

目的探讨艾滋病(AIDS)合并胶质瘤的临床特点、诊疗方案及可能的相关因素。方法回顾性分析2例AIDS合并胶质瘤患者的临床资料;并结合数据库检索相关文献,多因素分析不同因素对患者生存时间的影响。结果检索到31篇文献,符合标准的病例共35例。分析结果显示,不同诊疗方式患者的生存时间的差异有统计学意义(P=0.006);而年龄、性别、肿瘤部位及级别的不同对患者生存期的影响无统计学意义(均P>0.05)。结论对于AIDS合并胶质瘤患者,手术后放、化疗比活检后放、化疗更有助于延长其生存期。

Objection To explore the therapeutic schedule for glioma patients with acquired immunodeficiency syndrome （AIDS）. Methods We performed a quantitative and comprehensive systematic literature review of AIDS patient with glioma. Then using those cases conformed to inclusion criteria to make a statistical analysis to discuss different treatment, sex, grade, and location whether can influence the patients＇ lifetime respectively. Result We evaluated 59 patients from 31 studies, finally 35 cases were included our study depending on the inclusion criteria. Most of patients accepted radiotherapy （RT） and/or chemotherapy（CT） after resection or biopsy. We had carried out a survival analysis for the HIV patients suffered from glioma by different ways of diagnosis and treatment. The P value is 0. 006. The outcome has statistical significance. As for other factors, all P 〉 0.05, having no statistical significance. Conclusion As for those patients, surgical resection combined RT and/or CT is more contributing to extent the patients＇ median survival time and improve the quality of life than biopsy. However, the relationship between other factors and lifetime have no statistical significance.