氟比洛芬酯超前镇痛对腹腔镜下子宫肌瘤剔除术患者拔管期应激反应的影响

Impact of preemptive analgesia with flurbiprofen axetil on stress response of laparoscopic myomectomy patients in extubation period

目的探讨氟比洛芬酯超前镇痛对腹腔镜下子宫肌瘤剔除术患者拔管期应激反应的影响。方法 98例腹腔镜下子宫肌瘤剔除术患者,随机分为对照组和观察组,各49例。对照组:手术前无氟比洛芬酯超前镇痛;观察组:手术前给予患者氟比洛芬酯超前镇痛。观察并记录两组患者拔管即刻耐管情况和视觉模拟评分法(VAS)评分。结果观察组患者的耐管评分(0.9±0.3)分、疼痛VAS评分(1.4±0.3)分均低于对照组的(2.2±0.4)、(3.5±0.9)分,差异均有统计学意义(P<0.01)。结论麻醉诱导前给予氟比洛芬酯可部分抑制腹腔镜下子宫肌瘤剔除术导致的术后疼痛,有效的降低术后应激反应。

Objective To explore the impact of preemptive analgesia with flurbiprofen axetil on stress response of laparoscopic myomectomy patients in extubation period. Methods A total of 98 laparoscopic myomectomy patients were randomly divided into control group and observation group, with 49 cases in each group. The control group did not receive flurbiprofen axetil for preemptive analgesia before operation, and the observation group received flurbiprofen axetil for preemptive analgesia before operation. Observation and record were made on tube resistance at tube drawing immediate and visual analogue scale （VAS） score in two groups. Results The observation group had lower tube resistance score as （0.9 ±0.3） points and pain VAS score as （1.4 ± 0.3） points than （2.2 ± 0.4） and （3.5±0.9） points in the control group, and their difference had statistical significance （P〈0.01）. Conclusion Application of flurbiprofen axetil before anesthesia induction can partially inhibit postoperative pain induced by laparoscopic myomectomy and effectively decrease postoperative stress response