盐酸氨溴索治疗新生儿呼吸窘迫综合征的疗效分析

Analysis of curative effect of ambroxol hydrochloride in the treatment of neonatal respiratory distress syndrome

目的研究分析新生儿呼吸窘迫综合征应用盐酸氨溴索治疗的临床疗效。方法 80例新生儿呼吸窘迫综合征患儿,随机分为对照组及观察组,每组40例。对照组患儿进行常规对症治疗,观察组患儿在常规对症治疗的基础上给予盐酸氨溴索治疗。比较两组患儿治疗前后的[动脉血氧分压(PaO_2)、动脉血二氧化碳分压(PaCO_2)、氧合指数(PaO_2/FiO_2)]指标水平及患儿的氧疗时间、住院时间、并发症发生情况。结果治疗前,两组患儿的PaO_2、PaCO_2、PaO_2/FiO_2比较,差异均无统计学意义(P>0.05);治疗后,两组患儿的PaO_2较治疗前升高,PaCO_2、PaO_2/FiO_2较治疗前下降,且观察组改善程度优于对照组,差异均具有统计学意义(P<0.05)。观察组患儿的氧疗时间(62±16)h、住院时间(13.7±6.5)d、并发症发生率(2.5%)均优于对照组[(93±19)h、(19.3±7.9)d、17.5%],差异均具有统计学意义(P<0.05)。结论盐酸氨溴索用于治疗新生儿呼吸窘迫综合征具有较好的临床效果,不但可以改善患儿的血气分析指标,还可缩短患儿的氧疗时间和住院时间,降低不良反应发生率,值得在临床中广泛推广。

Objective To study and analyze the clinical curative effect of neonatal respiratory distress syndrome treated with ambroxol hydrochloride. Methods A total of 80 neonatal respiratory distress syndrome patients were randomly divided into control group and observation group, with 40 cases in each group. The control group received conventional symptomatic treatment, and the observation group also received ambroxol hydrochloride for treatment. Comparison were made on indexes levels [arterial partial pressure of oxygen（PaO2）, arterial partial pressure of carbon dioxide（PaCO2） and oxygenation index（PaO2/FiO2）] before and after treatment, time of therapy using oxygen, hospital stay time and occurrence of complications in two groups. Results Before treatment, both groups had no statistically significant difference in PaO2, PaCO2 and PaO2/FiO2（P〉0.05）. After treatment, both groups had higher PaO2 than before treatment, and lower PaCO2 and PaO2/FiO2 than before treatment, and the observation group had better improvement degree than the control group. their difference had statistical significance（P〈0.05）. The observation group had better time of therapy using oxygen as（62±16） h, hospital stay time as（13.7±6.5） d and incidence of complications as 2.5% than the control group [（93±19） h,（19.3±7.9） d and 17.5%], and their difference had statistical significance（P〈0.05）. Conclusion Ambroxol hydrochloride shows good clinical effect in treating neonatal respiratory distress syndrome, which can not only improve blood gas analysis indexes of children, but also shorten time of therapy using oxygen and hospital stay time and reduce incidence of adverse reactions. So it is worth wide promotion in clinic.