海藻酸钙海绵及其载银后的性能研究

Study on the Capacity of Calcium Alginate Sponge with or Without Silver Nanoparticles

采用机械搅拌发泡,内源凝胶法,制备了多孔海藻酸钙海绵及负载纳米银海藻酸钙海绵。实验结果如下:乙醇处理湿凝胶可加速干燥过程,保留海绵孔道结构;乙醇-甘油水溶液后处理,可获得具有一定柔韧性的海藻酸钙海绵;海绵经Ag NO3溶液浸渍,乙醇-甘油水溶液处理,80℃干燥,可得到载纳米银海藻酸钙海绵;改变乙醇-甘油水溶液含量,可调节海绵的吸液率、保液率和力学性能;载纳米银海藻酸钙海绵对金黄色葡萄球菌和大肠杆菌均具有良好的抑菌性能。

Porous calcium alginate （ALG-Ca） sponges with or without silver nanoparticles （AgNPs） were prepared by tailoring hydrogel to incorporate enough air and internal gelling method. The experiment re- sult was as follows： ALG-Ca wet sponge was disposed by using absolute ethyl alcohol to accelerate the process of drying and remain the porous structure to achieve ALG-Ca desiccated sponge, then ALG-Ca sponge with excellent flexibility was obtained through impregnating ALG-Ca desiccated sponge into alco- hol-glycerol aqueous solution. Moreover, ALG-Ca sponges were immerged into AgNO3 solution, then im- pregnated into alcohol-glycerol aqueous and dried at 80 ~C to prepare AgNPs-loaded ALG-Ca sponges. The change of water solution including various alcohol and glycerol has an influence on the liquid absorp- tion, liquid preservation and mechanical properties of Ca-ALG sponges. AgNPs-loaded ALG-Ca sponges showed good antibacterial capability against both Staphylococcus aureus and Escherichia coli.