彩色多普勒在早孕期诊断重度α地中海贫血胎儿中的应用

Application of Color Doppler in the Diagnosis of Severe α-thalassemia in Early Pregnancy

目的探讨彩色多普勒在早孕期诊断重度α地中海贫血胎儿中的应用价值。方法选择2013年2月—2016年10月在我医院产科进行产前检查,并且夫妻双方经过检查均确定为α地中海贫血基因携带者的孕妇100例作为病例组,选择同时间段内在我医院产科进行产前检查的健康者100例作为对照组,对患者进行基因检测和彩色多普勒检查,对检查的结果进行对比分析。结果在对照组与病例组患者的一般临床资料的比较中,两个组别的年龄、孕周、BMI几个项目的数据差异没有统计学意义(P>0.05),观察组患者中通过基因诊断得出重型α地中海贫血23例,占23.00%,中型α地中海贫血12例,占12.00%,轻型α地中海贫血42例,占42.00%,无α地中海贫血23例,占23.00%,经过彩色多普勒检查,病例组与对照组之间的大脑中动脉的收缩期流速峰值数值的差异具有统计学意义(F=13.559,P<0.05),经过t检验,只有重型α地中海贫血的数值与其他组别的数值差异具有统计学意义(P<0.05),其他各组的数据差异不具有统计学意义(P>0.05),可以看出重型α地中海贫血的数值显著高于其他组。结论运用彩色多普勒技术对胎儿进行重型的α地中海贫血的检查,是一种安全可靠并且无创性的检查方法。

Objective To explore the value of color Doppler in the diagnosis of severe α-thalassemia in early pregnancy. Methods From February 2013 to October 2016, 100 cases in my hospital obstetrics for prenatal examination, and both husband and wife were identified as α-thalassemia gent carriers of pregnant women as a case group, select the same period of time in my 100 cases of healthy subjects who were prenatal examination in the hospital obstetrics as a control group were tested for genetic testing and color Doppler examination. The results of the examination were compared and analyzed. Results The general clinical data in comparison to the control group and patient group patients in different age, gestational weeks, BMI several projects of the two groups of data was not statistically significant （P 〉 0.05）, the patients in the observation group that severe alpha thalassemia 23 cases, accounted for 23.00% of the diagnosis by gene in 12 cases of thalassemia, accounting for 12.00%, alpha thalassemia 42 cases, accounting for 42.00%, no alpha thalassemia in 23 cases, accounting for 23.00%, by color Doppler ultrasound. The difference between artery peak systolic velocity numerical case group and control group in the brain has statistical significance （F=13.559, P〈0.05）, after t test, statistically the significance of difference only numerical severe alpha thalassemia and other groups （P〈0.05） data, among other groups was not statistically significant （P〉0.05）, we can see that the heavy, the value of alpha thalassemia was significantly higher than that of other groups. Conclusion The use of color Doppler technique for the detection of heavy alpha-thalassemia in the fetus is a safe, reliable and noninvasive method of examination that deserves to be promoted in clinical context.