慢性阻塞性肺疾病合并抑郁/焦虑与细胞因子的相关性分析

Correlative Analysis of Depression and Anxiety in Chronic Obstructive Pulmonary Disease With Cytokines

目的探讨慢性阻塞性肺疾病(COPD)患者合并抑郁/焦虑情况及与白介素-8(IL-8)及肿瘤坏死因子-α(TNF-α)的相关性。方法选择200例COPD患者为研究对象,对入选患者依据肺功能进行分级,并采用综合医院焦虑抑郁量表(HAD)对患者进行评分,评估COPD患者焦虑/抑郁发生率及焦虑/抑郁的程度,并测定患者血清IL-8、TNF-α。结果对患者血清细胞因子与COPD患者HAD评分进行相关性分析,发现IL-8、TNF-α水平与COPD患者HAD评分呈正相关(P<0.01),中重度焦虑/抑郁的COPD患者中细胞因子IL-8、TNF-α高于轻度焦虑/抑郁的COPD患者,对比差异有统计学意义(P<0.01);相关系数分别为0.791、0.876。结论慢性阻塞性肺疾病合并焦虑/抑郁与炎症因子IL-8及TNF-α相关。

Objective Research the correlation with interlcukin-8 （IL- 8）, tumor necrosis factor alpha （TNF-α）,the anxiety/depression in patients with chronic abstructive pulmonary disease （COPD）. Methods 200 cases of COPD were selected as the research object, selected according to the classification of pulmonary function, and the hospital anxiety and depression scale （HAD） score of patients, assessment of anxiety / COPD in patients with depression and anxiety / depression degree rate, and determination of serum IL-8 and TNF-α. Results On serum cytokines in patients with HAD and COPD scores in the correlation analysis, found IL-8, TNF-α levels in patients with COPD positive HAD score （P〈0.01）, moderate to severe anxiety / depression cytokines in patients with COPD IL-8 and TNF-α is higher than that of mild anxiety / depression in patients with COPD, there was statistically significant difference （P〈0.01）, the correlation coefficients were 0.791 and 0.876. Conclusion The relationship of chronic obstructive pulmonary disease, anxiety/depression IL-8 and TNF-α is interrelate.