丁苯酞氯化钠联合依达拉奉对急性期脑梗死患者神经功能缺损及日常生活活动能力的影响

Effect of Butylphthalide and Sodium Chloride Combined With Edaravone on Neurological Deficits and Activities of Daily Living for Acute Cerebral Infarction

目的探讨丁苯酞氯化钠联合依达拉奉治疗急性期脑梗死患者对神经功能缺损评分和日常生活活动能力的影响。方法选择2015年12月—2016年11月在我院治疗的急性脑梗死患者60例为研究对象,随机分为联合组与对照组各30例。对照组给予常规治疗急性脑梗死治疗,联合组在对照组治疗基础上给予丁苯酞氯化钠及依达拉奉治疗。分别在入院时、治疗第7天及第14天采用CSS以及NIHSS量表对患者神经缺损情况进行评价,采用Barthel指数对患者日常生活活动能力进行评价。结果两组治疗后CSS、NIHSS评分显著下降,第7天及第14天低于入院时,差异有统计学意义(P<0.05);治疗第7天及第14天,联合组CSS评分低于对照组,差异有统计学意义(P<0.05)。两组治疗后,Barthel指数均显著升高,治疗第7天以及第14天显著高于入院时,差异有统计学意义(P<0.05)。治疗第7天及第14天,联合组Barthel指数高于对照组,差异有统计学意义(P<0.05)。结论丁苯酞氯化钠联合依达拉奉治疗急性期脑梗死能够显著改善患者神经功能缺损情况以及日常生活活动能力。

Objective To discuss the effect of Butylphthalide and sodium chloride combined with edaravone on neurological deficits and activities of daily living for acute cerebral inlarction. Methods 60 cases with acute cerebral infhrction ti＇om December 2015 to November 20l 6 were selected as subjects, and were divided randomly into combination group and control group, each of 30 eases. The control group was treated with conventional therapy, and combination group was treated with butylphthalide and sodium cfiloride combined with edaravone based on conventional therapy. CSS, NIHSS and Barthel index of two groups were compared. Results CSS and NIHSS scores after treated of two groups decreased, and the scores at the 7th day and the fourteenth day were louver than the score at the first day, which showed significant difference （P〈0.05）： CSS and NIHSS scores of combination group at the 7th day and the fourteenth day were lower than those of control group, which showed significant difference （P〈0.05）. Alter treatment, Barthel index of two groups increased, and the scores at the 7th day and the fourteenth day were higher than the score at the first day, which showed significant difference （P〈0.05）; Barthel index of cornbination group at the 7th day and the fourteenth day were higher than those of control group, which showed significant difference （P〈0.05）. Conclusion Butylphthalide and sodium chloride combined with edaravone for acute cerebral infarction can improve neurological deficits and activities of daily living.