辛伐他汀与阿司匹林联用对缺血性脑卒中二级预防临床研究

Clinical Study on Simvastatin Combined With Aspirin on Secondary Prevention of Ischemic Stroke

目的研究辛伐他汀与阿司匹林联用对缺血性脑卒中二级预防的疗效。方法选取我院神经内科2013年5月—2015年5月收治的缺血性脑卒中患者180例,随机分为对照组和试验组,各90例。对照组予以口服阿司匹林治疗,100 mg,睡前一次;试验组在口服阿司匹林的基础上,加用辛伐他丁,10 mg,睡前一次。治疗前后分别检测患者的总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)的变化,并观察两组患者出院后一年内缺血性卒中的复发率。结果试验组缺血性脑卒中患者一年复发率(3.33%)低于对照组(8.89%)(P<0.05);对照组TG、TC、LDL-C、HDL-C治疗后较治疗前差异无统计学意义(P>0.05);试验组患者TG、TC、LDL-C治疗后较治疗前降低(P<0.05),HDL-C治疗后较治疗前升高(P<0.05)。结论辛伐他汀与阿司匹林联用,对缺血性脑卒中的二级预防有良好的临床疗效。

Objective To study the effect of simvastatin combined with aspirin on secondary prevention of ischemic stroke. Methods 180 eases of ischemic stroke admitted to our hospital from May 2013 to May 2015 were randomly divided into control group and experimental group. Control group received oral aspirin treatment, 100 rag, once before going to bed. Test group in the oral aspirin on the basis of plus simvastatin, 10 rag,once before going to bed. The levels of TC, TG, LDL-C and HDL-C in the treatment group were measured belbre and after treatment. And to observe tile two groups of patients discharged within one year after the recurrence rate of ischemic stroke. Results The recurrence rate （3.33%） in the ischemic stroke patients was significantly lower than that in the control group （8.89%） （P 〈 0.05）. There was no significant difference in TG, TC, LDL-C and HDL-C between the two groups beibre treatment （P 〉 0.05）. The levels of TG, TC and LDL-C in the trial group were significantly lower than those before treatment （P 〈 0.05）. HDL-C treatment was significantly higher than belore treatment （P 〈 0.05）. Conclusion Simvastatin and aspirin in combination with the secondary prevention of ischemic stroke have a good clinical efficacy.