美沙拉嗪与柳氮磺吡啶治疗溃疡性结肠炎的疗效对比分析

Comparative Analysis of the Efficacy of Mesalazine and Sulfasalazine in the Treatment of Ulcerative Colitis

目的分析美沙拉嗪与柳氮磺吡啶治疗溃疡性结肠炎的临床效果。方法将62例UC患者随机分为观察组与对照组,每组31例。对照组使用柳氮磺吡啶,观察组使用美沙拉嗪,两个月后,分析临床效果。结果对照组治疗有效率为67.74%,观察组为93.55%。组间数据差异有统计学意义,P<0.05。观察组不良反应发生率为6.45%,对照组为25.81%,P<0.05。结论美沙拉嗪以及柳氮磺吡啶在治疗溃疡性结肠炎方面均有一定临床效果,但美沙拉嗪的安全性更高,治疗效果更好,更有利于患者疾病转归。

Objective To analyze the clinical effect of mesalazine and sulfasalazine in the treatment of ulcerative colitis. Methods 62 cases of UC patients were randomly divided into observation group and control group, each group of 31 cases. The control group was treated with sulfasalazine, and the observation group was treated with mesalazine. After two months, the clinical effect was analyzed. Results The effective rate of the control group was 67.74%, the observation group was 93.55%. There was significant difference between the two groups, P〈0.05. The incidence of adverse reactions in the observation group was 6.45%, the control group was 25.81%, P〈0.05. Conclusion Mesalazine and sulfasalazine in the treatment of ulcerative colitis have a certain clinical effect. However, mesalazine has higher safety and better treatment effect, which is more conducive to the prognosis of patients.