自拟疏木运土止咳方结合西医常规疗法治疗胃食管反流性咳嗽临床研究

Clinical effect ofShumu-Yuntu-Zhike decoction with converntional treatment for the gastroesophageal feflux cough

目的 观察自拟疏木运土止咳方结合西医常规疗法治疗胃食管反流性咳嗽（gastroesophageal reflux cough,GERC）的疗效.方法 将符合入选标准的64例GERC患者按随机数字表法分为2组,每组32例.对照组口服莫沙必利片与雷贝拉唑肠溶胶囊,治疗组在对照组基础上加服自拟疏木运土止咳方,2组均治疗8周.分别于治疗前后采用VAS评分法评价咳嗽强度,采用反流性疾病问卷（Reflux Diagnostic Questionnaire,RDQ）评价胃反流症状的变化,采用慢性咳嗽影响量表（Chronic Cough Impact Questionnaire,CCIQ）评价患者近2周咳嗽严重程度及对生活质量的影响.结果 治疗后4周,治疗组VAS评分[（4.47±1.32）分比（6.22±1.34）分,t=-5.859]、CCIQ评分[（32.60±5.83）分比（47.32±5.56）分,t=-11.548]较对照组降低（P〈0.01）,RDQ评分[（13.62±2.89）分比（13.67±2.77）分,t=-0.079]与对照组比较,差异无统计学意义（P〉0.05）.治疗后8周,治疗组VAS评分[（2.57±1.69）分比（4.55±2.06）分,t=-4.676]、CCIQ评分[（12.47±3.41）分比（23.47±3.55）分,t=-14.126]较对照组降低（P〈0.01）,RDQ评分[（9.18±2.77）分比（9.30±2.43）分,t=-0.202]与对照组比较,差异无统计学意义（P〉0.05）.治疗后,治疗组总有效率为90.6%（29/32）、对照组为68.8%（22/32）,2组比较差异有统计学意义（χ^2=4.730,P=0.030）.结论 自拟疏木运土止咳方结合西医常规疗法可较好改善GERC患者的反酸、咳嗽症状.

Objective To observe the clinical effect of Shumu-Yuntu-Zhike decoction with conventional treatment for the Gastroesophageal Reflux Cough （GERC）.Methods A total of 64 patients with GERC were randomly divided into the conventional treatment group and the combined treatment group, 32 in each. The conventional treatment group took the Rabeprazole capsule and Mosapride Citrate Tablets, and the combined treatment group received the traditional prescription of Shumu-Yuntu-Zhike decoction on the basis of the conventional therapy. Two groups were treated for 8 weeks and evaluated the effect with the Visual analogue scale （VAS）, Reflux diagnostic questionnaire （RDQ） and Chronic cough impact questionnaire （CCIQ） before and after 4 and 8 weeks＆#39; treatment.Results After 4 week treatment, the VAS （4.47 ± 1.32vs. 6.22 ± 1.34;t=-5.859,P〈0.01）, CCIQ （32.60 ± 5.83vs. 47.32 ± 5.56,t=-11.548,P〈0.01） in the combined treatment group decreased significantly than the conventional group, but the RDQ （13.62 ± 2.89vs. 13.67 ± 2.77;t=-0.079, P=0.937） showed no significant difference between the two groups. After 8 weeks＆#39; treatment. After 8 week treatment, the VAS （2.57 ± 1.69vs. 4.55 ± 2.06;t=-4.676,P〈0.01）, CCIQ （12.47 ± 3.41vs. 23.47 ± 3.55;t=-14.126,P〈0.01） in the combined treatment group decreased significantly, but the RDQ （9.18 ± 2.77vs. 9.3 ± 2.43,t=-0.202,P=0.841） showed no significant difference between the two groups. After the treatment, the total effective rate of combined treatment group was 90.6% （29/32）, while the control group was 68.7% （22/32）. There was significant difference between the two groups （χ^2=4.730,P=0.030）.Conclusions The therapy of Shumu-Yuntu-Zhike decoction combined with conventional therapy can relieve the symptom of gastroesophageal reflux cough.