美沙拉嗪联合益生菌对溃疡性结肠炎患者炎性因子及免疫功能的影响

The Effect of Mesalazine Combined With Probiotics on Inflammatory Factors and Immune Function in Patients With Ulcerative Colitis

目的探讨美沙拉嗪联合益生菌对溃疡性结肠炎(UC)患者炎性因子及免疫功能的影响。方法选择我院2016年1—11月收治的75例UC患者为研究对象,运用随机数字表法,将其分为观察组38例、对照组37例。对照组给予美沙拉嗪治疗,观察组加用益生菌,对两组患者免疫功能及炎性因子变化进行观察。结果治疗前,两组TNF-α、IL-6及CD4^+/CD8^+对比,差异无统计学意义(P>0.05);治疗后,观察组患者TNF-α、IL-6水平均低于对照组,CD4^+/CD8^+高于对照组,差异均具有统计学意义(P<0.05)。结论美沙拉嗪联合益生菌可有效控制UC患者炎性因子水平,促进免疫功能恢复。

Objective To study the mesalazine joint probioties inflammatory factors in patients with ulcerative colitis （UC） and the influence of immune function. Methods 75 cases of patients with UC in our hospital from January to November 2016 were selected as the research object. According to random number table method group, observation group of 38 cases, control group of 37 cases. Control group received the mesalazine treatment, observation group received probiotics, to observe immune function and inflammatory factors in patients with two groups of change. Results Before treatment, two groups of TNF alpha, IL-6 and CD4＋/CD8＋ no significant difference （P 〉 0.05）. After treatment, the observation group of patients with TNF alpha, IL - 6 levels significantly lower than the control group, CD4＋/ CD8＋ is significantly higher than the control group （P 〈 0.05）. Conclusion The mesalazine joint probiotics can effectively control the UC patients with inflammatory factor levels, promote immune function recovery, worth promotion.