不同剂量紫杉醇联合卡铂治疗晚期卵巢癌的疗效比较

Comparison of the Efficacy of Different Doses of Paclitaxel Combined With Carboplatin in the Treatment of Advanced Ovarian Cancer

目的分析不同剂量紫杉醇联合卡铂治疗晚期卵巢癌的临床疗效。方法将52例晚期卵巢癌患者随机分为两组,均给予300~400mg/m^2卡铂静滴3 h,另外对照组给予3h175 mg/m^2紫杉醇静滴,观察组给予24 h 135 mg/m^2紫杉醇静滴。结果两组治疗总有效率对比,差异无统计学意义(P>0.05),观察组不良反应发生率均低于对照组(P<0.05)。结论对晚期卵巢癌在卡铂治疗时给予3h 175 mg/m^2紫杉醇、24h 135mg/m^2紫杉醇静滴的疗效相当,但后者更为安全。

Objective To evaluate the clinical effect of different doses of paclitaxel combined with carboplatin in the treatment of advanced ovarian cancer. Methods 52 cases of patients with advanced ovarian cancer were randomly divided into two groups, were given intravenous drip of 3 h platinum 300 - 400 mg/m2, the control group was given 3 h 175 mg/m2 paclitaxel infusion, the observation group was given intravenous paclitaxel 24 h 135 mg/m2. Results The total efficiency of two groups had no significant difference （P 〉 0.05）. The adverse reaction rate of observation group were significantly lower than the control group （P 〈 0.05）. Conclusion For advanced ovarian cancer given 3 h 175 mg/m2 paclitaxel in carboplatin, 24 h 135 mg/m2 paclitaxel infusion efficacy, but the latter is more for safety.