270例全血细胞减少患者骨髓形态学及外周血检查结果分析

Analysis of bone marrow morphology and peripheral blood test result in 270 patients with pancytopenia

目的通过骨髓涂片、骨髓活检及外周血检查结果对全血细胞减少性疾病的病因及疾病特点进行探讨。方法对270例初诊全血细胞减少患者同步进行骨髓穿刺涂片及骨髓活检取材,染色后行骨髓形态学检查,并结合其血常规检查结果进行分析。结果 270例全血细胞减少患者中,血液系1统疾病占67.4%,其中以急性白血病最为常见,其次为再生障碍性贫血及骨髓增生异常综合征。骨髓涂片联合骨髓活组织检查能够提高全血细胞减少患者的确诊率。与非血液系统疾病相比,血液系统疾病患者的贫血症状更为严重。结论全血细胞减少性疾病范围广泛,病因复杂,多为血液系统疾病引起。骨髓涂片与骨髓活组织检查相结合,能客观准确地反映骨髓的真实情况.相比单一的骨髓涂片,更能够提高疾病诊断的准确性。

Objective To investigate the causes and clinical profile of pancytopenia through bone marrow smear, bone marrow biopsy, and peripheral blood examination. Methods We took the bone marrow aspiration and biopsy simultaneously in 270 newly-diagnosed patients with pancytopenia. When the staining was done, we observed them under miscory,and analyzed their haematological parameters. Results Among 270 patients who had pancytopenia, 67. 4% were from hematopoietic diseases. The most common disease was acute leukemia, followed by aplastic anemia and myelodysplastic syndrome. Compared with non-hemafologic diseases,anemia in patients with hematologic diseases was more serious. The combination of bone marrow aspiration and biopsy can improve the diagnosis rate of pancytopenia patients. Conclusion Pancytopenia is a common occurrence,and mostly caused by blood disorders. The combination of bone marrow aspiration and biopsy may accurately reflect the real situation of bone marrow. Compared to bone marrow aspiration,The combination of these two methods was able to improve the accuracy of diagnosis.