Survivin蛋白在甲状腺癌组织中的表达及其临床意义

The expression of Survivin in thyroid carcinoma tissues and its clinical significance

目的:探讨Survivin蛋白在甲状腺癌组织中的表达及其临床意义。方法:采用免疫组织化学染色法检测135例甲状腺乳头状癌(A组)、28例甲状腺滤泡癌(B组)、150例结节性甲状腺肿(C组)及150例正常甲状腺(D组)组织中Survivin的蛋白表达水平,并分析其与患者临床病理特征的关系。结果:A组和B组Survivin蛋白表达水平明显高于C组及D组(P<0.05),而A组与B组比较差异无统计学意义(P>0.05),C组与D组Survivin蛋白表达水平比较差异亦无统计学意义(P>0.05)。A组和B组患者中,临床分期(TNM分期)为Ⅲ期、Ⅳ期的患者Survivin蛋白表达水平明显高于Ⅰ期、Ⅱ期者(P<0.05);有淋巴结转移的患者Survivin蛋白表达水平明显高于无淋巴结转移者(P<0.05)。结论:Survivin蛋白在甲状腺癌组织中的表达显著上调,且与甲状腺癌患者的TNM分期、淋巴结转移情况密切相关,有望成为甲状腺癌临床诊断、治疗的重要靶点以及预后评估的重要指标。

Objective：To investigate the expression of Survivin in thyroid carcinoma and its clinical significance. Methods： The thyroid tissues from 135 patients with papillary thyroid carcinoma （group A） ,28 patients with thyroid follicular carcinoma （group B）, 150 patients with nodular goiter （group C） and 150 health subjects （group D） were collected. The protein expression of Survivin in thyroid tissues was detected by immunohistochemical staining. Results： The expression of Survivin in group A and group B was significantly higher than those in group C and group D （ P 〈0.05）. No significant differences in Survivin expression were detected between group A and group B,or between group C and group D （ P 〉0.05）. Tissues of group A and B in Ⅲ-Ⅳ clinical stages had higher expression of Survivin than those in Ⅰ- Ⅱ stages （P 〈0. 05）. Moreover, the expression of Survivin was higher in patients with lymph node metastasis than those without （ P 〈0.05）. Conclusion： The protein expression of Survivin in thyroid carcinoma tissues was evidently up-regulated,and was closely related to the TNM stage and lymph node metastasis. It could be an important target for clinical diagnosis, treatment and prognosis evaluation in thyroid carcinoma patients.