平阳霉素联合微波热凝治疗小儿体表血管瘤的临床疗效观察

Clinical effect of pingyangmycin combined with microwave coagulation therapy on the treatment of hemangioma

目的:观察平阳霉素联合微波热凝治疗小儿体表血管瘤的临床效果。方法:选择2015年3月至2016年8月广西玉林市妇幼保健院收治的180例血管瘤患儿,随机分为A组、B组和C组,每组60例。A组患儿给予平阳霉素瘤体内注射联合微波热凝术治疗,B组单纯采用平阳霉素瘤体内注射治疗,C组单纯采用微波热凝治疗。观察3组患儿的治疗总有效率及不良反应发生率。结果:A组治愈38例,好转16例,治疗总有效率为90.00%;B组治愈20例,好转16例,总有效率为60.0%,C组治愈18例,好转15例,总有效率为55.0%。A组治疗总有效率显著高于B组和C组(χ2=19.872,P<0.001)。少数患儿出现局部疼痛、肿胀不适等轻微症状,3组均未见严重不良反应。结论:平阳霉素联合微波热凝治疗小儿体表血管瘤的疗效较好,不良反应少,安全性较高。

Objective： To observe the clinical effect of the treatment of hemangioma with pingyangmycin combined with microwave coagulation therapy. Methods： 180 patients with hemangioma treated in the maternal and child health hospital of Yulin City from March 2015 to August 2016 were randomly divided into group A ,B and C, with 60 cases in each group. Patients in group A received pingyangmycin in tratumoral injection combined with microwave coagulation therapy; patients in group B received pingyangmycin in tratumoral injection, while in group C received simple microwave coagulation therapy only. Total effective rate and the incidence of adverse reactions were observed and compared among three groups. Results： In group A, 38 cases were cured, 16 cases improved and the total effective rate was 90.00% ; in group B, 20 cases were cured, 16 cases improved, and the total effective rate was 60.0%; in group C, 18 cases were cured, 15 cases improved and the total effective rate was 55.0%. Total effective rate of group A was significantly higher than those of group B and group C （X2= 19. 872, P d0. 001）. A small number of children appeared mild symptoms such as local pain, swelling and discomfort. No serious adverse reaction was found in all three groups. Conclusion： The combination of pingyangmycin and microwave coagulation therapy was effective in the treatment of hemangioma with less adverse reaction.