乳腺癌患者化疗前后血清Ca、P、Mg、Zn含量与疗效的关系

Breast Cancer Before and After Chemotherapy in Patients with Serum Ca,P,Mg,the Relationship Between Zinc Content and Curative Effect

目的探讨乳腺癌患者化疗效果对血清中钙(Ca)、磷(P)、镁(Mg)以及锌(Zn)含量的影响。方法选取普宁市人民医院进行化疗的乳腺癌患者80例作为化疗组,观察患者化疗前后血清中Ca、P、Mg以及Zn的水平变化,另选80例健康女性作为健康人组,检测其血清Ca、P、Mg、Zn水平,并进行对比分析。结果化疗组Ca、Mg含量明显低于健康人组(P<0.05),Zn含量明显高于健康人组(P<0.05),P含量与健康人组相比无统计学意义(P>0.05);化疗后Ca、Mg含量显著高于化疗前(P<0.05),Zn含量显著低于化疗前(P<0.05),P含量略低于化疗前(P>0.05)。结论血清Ca、P、Mg、Zn含量随着临床治疗效果所变化,可作为检测化疗效果的有效反应因子,在疗效判定方面具有一定的参考价值。

Objective To study the effect of breast cancer patients with chemotherapy on serum calcium （Ca）,phosphorus （ P ） and magnesium （ Mg） and the influence of content of zinc （ Zn ） . Methods Choose 80 cases on the chemotherapy of breast cancer patients as chemotherapy group, were observed before and after chemotherapy in patients with serum Ca, P , Mg and zinc level changes, choose 80 cases of healthy women as healthy people group, detect the serum Ca, P , Mg, zinc levels, and comparison analysis. Results Chemotherapy group, Ca, Mg content significantly lower than the healthy group （P 〈 0？ 05 ） , zinc content is significantly higher than the healthy group （ P 〈 0？ 05 ） , P content in comparison with healthy group had no statistical significance （P 〉0.05）; Ca, Mg content were significantly higher after chemotherapy before chemotherapy （P 〈 0. 05） , the zinc content is significantly lower than before treatment （ P 〈 0. 05 ） , the P content is slightly lower than before treatment （ P 〉 0. 05 ）. Conclusion Serum Ca, P , Mg and zinc content changes as the clinical therapeutic effect, can be used for effective detection of chemotherapy response factors, in terms of outcome has a certainreference value.