D-二聚体、N-末端B型钠尿肽前体、心肌肌钙蛋白T及降钙素原联合检测对急性主动脉夹层预后判断的分析

Analysis of Prognosis Judgment of Combined Test of D-dimer, N-terminal Probrain Natriuretic Peptide, Cardiac Troponin TcTnT and Procalcitonin on the Acute Aortic Dissection

目的探讨D-二聚体、N-末端B型钠尿肽前体、心肌肌钙蛋白T及降钙素原对急性主动脉夹层预后的判断价值。方法整群收集2014年12月—2016年6月因胸痛在该院就诊初诊为急性主动脉夹层的患者143例,进一步分为52例研究组(发生死亡)和91例对照组(未发生死亡),对比1研究组和对照组一般资料;2研究组和对照组D-二聚体、N-末端B型钠尿肽前体、心肌肌钙蛋白T及降钙素原水平。结果 1研究组和对照组一般资料(性别、年龄、吸烟史)分别为[(男性49例、女性3例、(54.2±12.6)岁、(8.5±2.1)年]、[(男性82例、女性9例、(53.1±13.4)岁、(9.1±3.6)年],比较差异无统计学意义(P>0.05)。2研究组和对照组D-二聚体、N-末端B型钠尿肽前体、心肌肌钙蛋白T及降钙素原分别为[(9.16±2.38)μg/m L、(845.2±263.4)pg/m L、(75.3±6.34)pg/m L、(1.63±0.24)ng/m L;(3.51±1.26)ug/m L、(251.3±156.2)pg/m L、(12.35±5.47)pg/m L、(0.41±0.16)ng/m L],比较差异有统计学意义(P<0.05)。结论 D-二聚体、N-末端B型钠尿肽前体、心肌肌钙蛋白T及降钙素原联合检测对急性主动脉夹层预后判断有较好价值。

Objective To d iscu ss th e prognosis ju d gm en t of comb in ed te s t of D -d ime r , N- te rmin a l p ro b ra in n a tr iu re t ic p e p -t ide, cardiac troponin T cTnT and procalci tonin on the acute aort ic dis section. Methods Group s ele ct ion 143 cases of p a -tients with acute aort ic dis sect ion treated in our hospi tal from December 2014 to June 2016 due to chest pains were col lect-ed and divided into the research group with 52 cases （death） and the control group with 91 cases （no death） , and the general data, D-dimer , N-terminal probrain natr iuret ic pept ide, cardiac troponin T cTnT and procalci tonin levels of the two groups were compared. Results The d ifferences in th e g en e ra l d a ta in c lu d in g g en de r, age and smoking history b etwe en th e re se a rch group and the control group had no stat ist ical signif icance（49 male cases , 3 female cases （54.2±12.6） years old and （8.5土 2.1） and [（82 male cases , 9 female cases , （53.1±13.4） years old, （9.1±3.6）years] had no stat ist ical signif icance（P〉0.05）. The differences in the D-dimer, N-terminal probrain natr iuret ic pept ide, cardiac troponin T cTnT and procalci tonin levels be-tween the research group and the control group had stat ist ical s ignif icance [（9.16±2.38）ug/mL, （845.2±263.4）pg/mL, （75.3土 6.34）pg/mL,（1.63±0.24）ng/mL];（3.51±1.26）滋 g /mL,（251.3±156.2）pg/mL,（12.35±5.47）pg/mL, （0.41±0.16）ng/mL]（P〈0.05）. Con-clusion The value of prognosis ju d gmen t of combined te st of D-dime r , N- te rminal p ro b ra in n a tr iu re t ic p ep t id e , c a rd ia c tro -ponin T cTnT and procalci tonin on the acute aort ic dis sect ion is better .