植物萜类化合物生物合成与调控及其代谢工程研究进展

Biosynthesis,Regulation and Metabolic Engineering of Terpenoids in Plants

萜类化合物大多属于次生代谢产物,在自然界中分布广泛、数量众多,并且结构和功能多样,在药品、农业和工业生产中应用广泛。近年来人们对植物萜类化合物进行了大量深入的研究,主要包括萜类化合物的分离鉴定和药理研究,生物合成相关基因的克隆和相关酶的功能鉴定,以及代谢工程等方面。文章从植物萜类化合物的生物合成和调控以及代谢工程进行综述,分析了植物中萜类化合物的研究进展。

Terpenoids are widespread in nature that have various types, multiple structures and functions, most of which belong to secondary metabolites. In addition,terpenoids have been widely applied to drug development, agricultural purposes and industrial production. Plant terpenoids have been deeply investigated due to their new functions in recent years, including isolation, identification, pharmacological research, biosynthetic genes cloning, functional identification of enzymes and metabolic engineering. The biosynthesis and regulation of plant terpenoids along with metabolic engineering were discussed in this review.