来氟米特联合激素治疗难治性肾病综合征效果分析

Analysis of General Effect of Leflunomide and Hormone in Treatment of Refractory Nephrotic Syndrome

目的分析用来氟米特联合激素治疗的方法 ,在针对性治疗难治性肾病综合征患者时进行临床效果观察。方法方便选取2013年11月—2015年10月该医院就诊的84例难治性肾病综合征患者为研究对象,根据治疗方法的不同,将患者随机分组,采用来氟米特联合激素(醋酸泼尼松)治疗的患者为"治疗组";采用环磷酰胺联合激素治疗的为"对照组",每组42例。将两组患者的血白蛋白、血肌酐、24 h尿蛋白定量等相关指标水平在治疗前和治疗后4个月所发生的变化进行对比,同时分析两种不同治疗方法的治疗效果。结果治疗组、对照组患者经治疗后病情均有好转,治疗组尿蛋白定量水平为(2.5±0.5)g/24 h,血白蛋白水平为(32.7±3.8)g/L,血肌酐水平为(72.4±7.8)μmol/L;治疗组、对照组的治疗总有效率分别为92.8%、69.0%,治疗组患者的治疗效果相比对照组明显要好,差异有统计学意义(P<0.05)。结论采用来氟米特联合激素治疗难治性肾病综合征患者时患者反映良好,临床效果较理想,患者不良反应发生率较低,在临床上有较高的推广价值。

Objective To analyze the clinical effect of leflunomide and hormone in treatment of refractory nephrotic syndrome. Methods 84 cases of patients with refractory nephrotic syndrome diagnosed in our hospital from November 2013 to October 2015 were selected and randomly divided into two groups with 42 cases in each according to different treatment methods, the treatment group were treated with leflunomide and hormone(prednisone acetate), the control group were treated with cyclophosphamide and hormone, and the changes of blood albumin, serum creatinine and 24 h urine protein before treatment and in 4 months after treatment were compared, at the same time, the treatment effect of the different methods was analyzed. Results After treatment, the disease conditions of the two groups were improved, and the urine protein level,blood albumin and serum creatinine in the treatment group were respectively(2.5±0.5)g/24 h,(32.7±3.8)g/L and(72.4±7.8)μmol/L, and the total effective rate in the treatment group and in the control group was respectively 92.8% and 69.0%, and the treatment effect in the treatment group was obviously better than that in the control group, and the difference was statistically significant(P<0.05). Conclusion The clinical effect of leflunomide and hormone in treatment of refractory nephrotic syndrome is ideal, and the incidence rate of adverse reactions is lower, which is of higher promotion value in clinic.