人参超微粉及水提物对自发性高血压大鼠血压的影响

Hypotensive effect of Superfine powder of Panax ginseng and Aqueous extract of Panax ginseng on spontaneous hypertensive rats

目的观察人参超微粉及水提物对自发性高血压大鼠(SHR)的降压作用。方法将80只SHR随机分为对照组、阳性药卡托普利组、人参超微粉0.5、1.0、2.0g/kg组及人参水提物0.1、0.2、0.4g/kg组,每组10只。采用尾动脉测压法测量给药前及给药后1、3、7、10、15、30、45、60、75、90天大鼠血压,对比人参超微粉及水提物对SHR的急性降压作用和慢性降压作用。结果人参超微粉1.0g/kg组于给药15、30、45、60、75、90天可使SHR收缩压明显降低(P<0.05或P<0.01),于给药30、45、60、75、90天可使SHR舒张压明显降低(P<0.05或P<0.01),人参超微粉0.5g/kg及人参水提物0.4g/kg组于给药45、60、75、90天可使SHR收缩压及舒张压均明显降低(P<0.05),人参超微粉0.25g/kg及人参水提物0.1、0.2g/kg组对SHR各时间点的收缩压及舒张压均无明显影响(P>0.05)。结论人参超微粉及水提物不具有急性降压作用,长期服用可产生降压作用,人参超微粉的作用优于人参水提物。

Objective To study hypotensive effect of superfine powder of Panax ginseng and aqueous extract of Panax ginseng on spontaneous hypertensive rats. Methods SHR were randomly divided into control group, malotilate group, superfine powder of Panax ginseng 0.25, 0.5 and 1.0 g/kg groups and aqueous extract of Panax ginseng 0.1, 0.2 and 0.4 g/kg groups. The systolic blood pressure and diastolic blood pressurein of SHR were determined in 0, 1, 3, 7, 10, 15, 30, 45, 60, 75 and 90 days. Results After treated by superfine powder of Panax （in a dosage of 1.0 g/kg） for 15, 30, 45, 60, 75 and 90 days, the systolic blood pressure was significantly decreased and the diastolic blood pressurein was significantly decreased for 30, 45, 60, 75 and 90 days. The systolic blood pressure and diastolic blood pressurein were alsO significantly decreased by superfine powder of Panax ginseng （in a dosage of 0.5 g/kg） and aqueous extract of Panax ginseng（in a dosage of 0.4 g/kg） for 45, 60, 75 and 90 days. Conclusion The superfine powder of Panax ginseng and aqueous extract of Panax ginseng have not acute hypotensive effect but have chronic therapeutic effect.