复方丹参滴丸联合阿托伐他汀治疗2型糖尿病伴急性脑梗死患者的疗效

Effect of Danshen dropping pill of combined with atorvastatin calcium in treatment of patients with type 2 diabetes and acute cerebral infarction

目的 :评价复方丹参滴丸联合阿托伐他汀治疗2型糖尿病合并急性脑梗死患者的疗效。方法 :收集2012年10月—2015年12月收治的2型糖尿病合并急性脑梗死患者136例,随机分为观察组和对照组各68例。除给予常规治疗外,对照组口服阿托伐他汀钙10 mg/d,观察组口服阿托伐他汀钙(10 mg/d)和复方丹参滴丸(3次/d)。治疗6个月后,观察两组患者血脂、炎症因子水平、颈动脉斑块总数和面积、斑块内膜-中层厚度(IMT)、易损斑快检出率,并比较治疗前后神经功能缺损程度(NIHSS)评分。结果 :观察组总胆固醇、低密度脂蛋白和三酰甘油水平显著低于对照组(P<0.05),高密度脂蛋白显著高于对照组(P<0.05),斑块面积与易损斑块检出率显著低于对照组(P<0.05),观察组C反应蛋白、白细胞介素6和肿瘤坏死因子α显著低于对照组(P<0.05)。结论 :复方丹参滴丸联合阿托伐他汀治疗脑梗死合并糖尿病患者能改善颈动脉粥样硬化,调节血脂,降低炎症因子水平,具有较高安全性。

Objective： Evaluate the effect of Danshen Dripping Pills combined with atorvastatin calcium in treatment of type 2 diabetes mellitus with acute cerebral infarction. Methods： Results After 6 months of treatment, the levels of blood lipids and inflammatory factors, the total number of carotid plaques, the area of intima-media thickness （IMT） and the susceptibility of plaque were detected and compared. The NIHSS score before and after treatment were compare. Results： The levels of TC, LDLC and TG in the observation group were significantly lower than those in the control group（P〈0.05）, the levels of HDLCwas significantly higher than control group（P〈0.05）; There was no significant difference in IMT and plaque number between observation group and control group（P〉0.05）. The detection rate of plaque area and vulnerable plaque was significantly lower than that of control group（P〈0.05）; level of CRP, IL-6 and TNF-α in the observation group were significantly lower than control group（P〈0.05）; NIHSS score in observation group were significantly lower than control group. Canelusions： Danshen Dropping pill combine with atorvastatin calsium is a effective method to improve carotid atherosclerosis, regulate blood lipid and decrease the level of inflammatory factors in type 2 diabets combine with cerebral infarction pations.