高压氧治疗对出血性脑卒中合并肺部感染的疗效及对血清PCT和hs-CRP水平的影响

Effect of hyperbaric oxygen therapy on serum levels of high sensitive C-reactive protein and procalcitonin in patients with hemorrhagic stroke complicated by pulmonary infection

目的探讨高压氧治疗对出血性脑卒中合并肺部感染的疗效及对血清降钙素原(PCT)和超敏C-反应蛋白(hs-CRP)水平的影响。方法 2010年1月至2016年1月收治出血性脑卒中120例,按治疗方法分为观察组和对照组,每组60例。对照组给予常规治疗,观察组在对照组治疗基础上加用高压氧治疗。治疗前和治疗后1个月测定血清PCT和hs-CRP水平。结果观察组治疗有效率(91.67%,55/60)显著高于对照组(78.33,47/60;P<0.05);而且,观察组感染消除时间[(8.9±4.1)d]较对照组[(10.7±5.3)d]显著缩短(P<0.05)。两组治疗前血清PCT、hs-CRP水平无统计学差异(P>0.05);治疗后1个月,两组血清PCT、hs-CRP水平较治疗前显著降低(P<0.05),而且,观察组降低更明显(P<0.05)。结论高压氧改善出血性脑卒中合并肺部感染的治疗效果,可能与降低炎症反应有关。

Objective To investigate the effect of hyperbaric oxygen therapy on the serum levels of procalcitonin （PCT） and high sensitive C-protein （hs-CRP） in the patients with hemorrhagic stroke complicated by pulmonary infection. Methods One hundred and twenty patients with hemorrhagic stroke complicated by pulmonary infection were divided into control group, in which 60 received the conventional treatment and observed group, in which 60 received hyperbaric oxygen besides the conventional treatment. The curative effects and the serum levels of PCT and hs-CRP were compared between both the groups. Results The effective rate （91.67%, 55/60） was significantly higher in the observed group than that （78.33%, 47/60） in the control group （P〈0.05）. The time of elimination of the infection was significantly shorter in the observed group than that in the control group （P〈0.05）. The serum levels of PCT and hs-CRP were significantly lower in the observed group than those in the control group 1 month after the treatment. Conclusion The therapeutic effect can be improved by hyperbaric oxygen therapy in the patients with cerebral hemorrhagic stroke complicated by pulmonary infection. It is suggested that the improvement of the curative effects produced by hyperbaric oxygen may be related to the decrease of inflammatory reaction.