63109例上海地区孕妇部分产前筛查指标分析

Prenatal screening for 63 109 pregnant women in Shanghai

目的了解上海地区孕妇部分产前筛查相关指标[丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、乙型肝炎表面抗原(HBs Ag)、抗丙型肝炎病毒(HCV)抗体、抗人类免疫缺陷病毒(HIV)抗体、抗梅毒螺旋体(TP)抗体]的阳性情况。方法检测2013—2016年63 109例孕妇ALT、AST、HBs Ag、抗HCV抗体、抗HIV抗体、抗TP抗体,并对结果进行分析。结果在同一年份中,高龄(>35岁)孕妇HBs Ag、抗TP抗体、ALT、AST阳性率明显高于适龄(≤35岁)孕妇(P<0.01),抗HCV抗体2个组之间差异无统计学意义(P>0.05)。2013—2016年间,HBs Ag阳性率呈逐年降低趋势(P<0.05),而抗TP抗体阳性率呈逐年上升趋势(P<0.05),其他指标各年份组间差异无统计学意义(P>0.05)。有异常孕产史的孕妇抗TP抗体阳性率明显高于正常孕妇(P<0.01),其他指标2个组之间差异无统计学意义(P>0.05)。结论检测孕妇产前筛查相关指标有助于了解孕妇相关疾病的患病情况,对促进优生优育有着重要的意义。

Objective To evaluate the results of prenatal screening for pregnant women in Shanghai,including the indices of alanine aminotransferase （ALT）, aspartate aminotransferase （AST）, hepatitis B surface antigen （HBsAg）, anti-hepatitis C virus （HCV） antibody, anti-human immunodeficiency virus （HIV） antibody and anti-treponema pallidum （TP） antibody. Methodse The levels of ALT, AST, HBsAg,anti-HCV antibody,anti-HIV antibody and anti-TP antibody were determined in 63 109 pregnant women from 2013 to 2016. Results The positive rates of HBsAg,anti-TP antibody,ALT and AST were higher in 〉35-year-old group than those in ≤35-year-old group （P〈0.01）. There was no statistical significance for the positive rate of anti-HCV antibody between the 2 groups （P〉0.05）. The positive rate of HBsAg had a decreasing trend from 2013 to 2016 （P〈0.05）. The positive rate of anti-TP antibody had an increasing trend （P〈0.05）,and there was no statistical significance for the other indices from 2013 to 2016 （P〉0.05）. The women with abnormal pregnancy history had a higher positive rate of anti-TP antibody compared with healthy pregnant women （P〈0.01）,and other indices had no statistical significance between the 2 groups（P〉0.05）. Conclusions Prenatal screening may contribute to understand the prevalence of diseases in pregnant women,which is beneficial for good prenatal and postnatal care.