台州地区表观健康成人血清补体C1q参考区间的初步建立

Establishment on the reference ranges of serum complement C1q among apparently healthy adults in Taizhou

目的探讨浙江台州地区表观健康成年人群血清补体C1q参考区间的建立,并分析血清补体C1q水平与其他常用临床检测指标的相关性。方法随机选取2016年2—3月在台州市中心医院进行健康体检的表观健康人群463名,其中男240名、女223名;采用免疫透射比浊法测定血清中补体C1q的含量;采用正态分布法的双侧95%可信区间确定参考区间。结果血清补体C1q水平在研究人群中呈正态分布,健康成人女性血清含量为(210.3±25.6)mg/L,高于男性的(197.8±26.1)mg/L(P<0.01)。相关分析显示,血清补体C1q与球蛋白、白细胞(WBC)、总胆固醇(TC)呈正相关(r>0,P<0.05),与血肌酐(Cr)、血红蛋白(Hb)呈负相关(r<0,P<0.05),与年龄等无相关性(P>0.05)。结论健康成人血清补体C1q的含量存在性别差异,建议不同性别的台州地区人群分别建立补体C1q的参考范围。

Objective To establish the reference ranges of serum complement C1q among apparently healthy adults in Taizhou,and to investigate the relationship between complement C1q and other parameters. Methodse A total of 463 apparently healthy adults were enrolled in Taizhou Central Hospital from February 2016 to March 2016,including 240 males and 223 females. Serum complement C1q was determined by turbidimetric inhibition immunoassay. The reference ranges were expressed by bilateral 95% confidence interval of normal distribution. Results The levels of complement C1q were expressed as normal distribution. The level of complement C1q in females [（210.3±25.6） mg/L] was higher than that in males [（197.8±26.1） mg/L]（P〈0.01）. Complement C1q had positive correlations with globulin,white blood cell （WBC）,total cholesterol （TC） （r〉0,P〈0.05）,and had negative correlations with creatinine （Cr） and hemoglobin （Hb）（r〈0,P〈0.05）. There was no correlation with ages （P〉0.05）. Conclusions The level of complement C1q in healthy adults has difference between males and females. The reference ranges of complement C1q should be established for males and females in Taizhou respectively.