动态血糖监测系统对糖尿病合并肾病患者的血糖波动幅度分析及对患者肾功能的作用

Analysis of Effect of Dynamic Monitoring System of Blood Glucose on the Blood Glucose Fluctuation Range of Patients with Diabetes and Renal Disease and Renal Function of Patients

目的探讨动态血糖监测系统对糖尿病合并肾病患者的血糖波动幅度及对肾功能影响。方法随机选取2016年8—12月于该院就诊的2型糖尿病肾病患者46例为观察组,并选取同期单纯2型糖尿病患者46例作为对照组,采用动态血糖监测系统监测两组患者3d的血糖波动,并观察两组患者肾功能指标变化。结果两组患者的日内血糖最大波动幅度、血糖最大值、24 h血糖水平标准差对比差异无统计学意义(P>0.05);但观察组患者24 h血糖平均水平、日间血糖平均绝对差、血糖最小值均显著大于对照组(P<0.05);观察组患者24 h尿蛋白定量(248.62±38.37)mg/24h、尿微量白蛋白(33.71±3.05)mg/g·cr、尿β2-微球蛋白水平(0.56±0.07)mg/L均显著高于对照组(P<0.05)。结论糖尿病肾病患者的平均血糖高于单纯糖尿病患者,并且持续长时间高血糖状态,日间血糖波动幅度较大,损害患者肾功能。采用动态血糖监测系统监控糖尿病肾病患者的血糖波动,并有效控制血糖,能够减少肾病发生。

Objective To study the effect of dynamic monitoring system of blood glucose on the blood glucose fluctuation range of patients with diabetes and renal disease and renal function of patients.Methods 46 cases of patients with type 2diabetic nephropathy diagnosed in our hospital from August to May December 2016 were randomly selected and 46 cases of patients with simple type 2 diabetes at the same period were selected as the control group,and the blood glucose fluctuation at 3d was monitored by the dynamic monitoring system and the renal function index changes of the two groups were observed.Results The differences in the maximum fluctuation range of daily blood glucose,maximum value of blood glucose and 24 h blood glucose level standard deviation between the two groups were not obvious without statistical significance(P>0.05),but the average level of 24 h blood glucose,av erage absolute difference of daily blood glucose and minimum value of blood glucose were obviously higher than those in the control group(P<0.05),and the 24 h urine protein quantitation,microalbuminuria and urinary beta-2 microglobulin in the observation group were respectively(248.62±38.37)mg/24 h,(33.71±3.05)mg/g·cr and(0.56±0.07)mg/L,which were obviously higher than those in the control group(P<0.05).Conclusion The average blood glucose in patients with diabetic nephropathy is higher than that of patients with simple diabetes,and the long-time high blood glucose state and big fluctuation range of daily blood glucose can be harm to the renal function of patients,and the dynamic monitoring system of blood glucose fluctuation of patients with diabetic nephropathy and effectively controlling the blood glucose can reduce the occurrence of nephropathy.