高血压患者前瞻性记忆功能研究

Study of prospective memory in patients with hypertension

目的探讨高血压患者(HP)与健康人群(HC)前瞻性记忆方面的差异,并分析HP组血压升高水平与前瞻性记忆损伤的相关性。方法选取2014年11月至2015年12月淮南第一人民医院50名HP患者及同时期50例HC作为研究对象,前瞻性记忆检测采取基于事件前瞻记忆任务正确数和基于时间前瞻记忆任务正确数,比较两组间前瞻性记忆的差异;采用Pearson相关分析比较HP血压升高与前瞻性记忆之间的相关性。结果采用焦虑自评量表和抑郁自评量表排除焦虑及抑郁情绪,HP组在基于事件和时间的前瞻性记忆差于HC组[(3.74±0.78)分vs(4.16±0.79)分;(3.32±1.11)分vs(4.08±0.75)分],差异有统计学意义(P<0.05);HP组舒张压水平与基于时间前瞻记忆得分呈负相关(r=-0.284,P=0.046)。结论 HP存在前瞻记忆方面的损伤,HP基于事件前瞻记忆损伤程度与舒张压水平密切相关。

Objective To explore the differences of the prospective memory between the patients with hypertension and the normal controls. Methods A total of 50 patients with hypertension from the First People＇s Hospital in Huainan during Nov 2014 and Dec 2015 were compared with matched 50 healthy controls. Correct number of Event-based prospective memory（EBPM） task and time-based prospective memory（TBPM） task were used to measure the difference of prospective memory between the two groups. Pearson correlation was used to analyze the correlations between the degree of blood pressure and the injury of prospective memory in hypertension group. Results Participants with anxiety or depression had to be excluded by self-rating anxiety scale and self-rating depression scale. Patient group＇s performance of EBPM and TBPM was worse than that of healthy control[（3.74±0.78）score vs （4.16±0.79） score; （3.32±1.11）score vs （4.08±0.75）score]（P〈0.05）. In patient group, systolic blood pressure showed negative correlation to EBPM（r=-0.284, P=0.046）. Conclusion Patients with hypertension has impairment in all prospective memory. The deficit degree of EBPM in patients is closely related to diastolic blood pressure.