电火针联合中药灌肠治疗溃疡性结肠炎临床疗效

Clinical efficacy and influence of inflammatory factor in patients with ulcerative colitis by electric-needle with TCM enema

目的观察电火针联合中药灌肠治疗溃疡性结肠炎临床疗效及对炎性因子的影响。方法将90例溃疡性结肠炎患者分为治疗组47例和对照组43例。治疗组给予电火针联合中药灌肠疗法,对照组给予口服柳氮磺吡啶结肠溶胶囊治疗。治疗6周,观察并比较2组患者症状、肠镜检查黏膜情况、组织病理积分、IL-6、IL-8、CRP及TNF-α水平、肝肾功与生活质量各个功能得分。结果治疗后治疗组患者症状、肠镜检查黏膜情况及组织病理积分均低于对照组(P<0.05);治疗组患者IL-6、IL-8、CRP及TNF-α亦低于对照组(P<0.05);治疗组总有效率高于对照组(P<0.05);治疗后2组患者情感功能、自我感知和社会功能评分均高于治疗前,治疗组治疗前后评分差值高于对照组(P<0.05);肝肾功能各值比较差异无统计学意义(P>0.05)。结论电火针联合中药灌肠疗法治疗溃疡性结肠炎疗效较好且安全性高。

Objective To observe clinical efficacy and influence of inflammatory factor of electric - needle with TCM enema in the treatment of ulcerative colitis. Methods 90 patients with ulcerative colitis were randomly divided into observation group （ n = 47 ） and control group （n = 43 ）. The observation group was given treatment of electric - needle with TCM enema; and the control group was treated with sulfasalazine colon soluble capsules orally. After 6 weeks＇ treatment, symptom scores, mucous membrane scores evaluated by colonoscopy and pathological scores colon tissue, and the level of IL - 6, IL - 8, CRP and TNF - , liver and kidney function and the score of life quality of two groups were observed and compared. Results After treatment, the symptom scores, mucous membrane scores evaluated by colonoscopy and pathological scores colon tissue, the level of IL - 6, IL - 8, CRP and TNF - α in observation groups were lower than those of control group （ P 〈 0.05 ）. While the total effective rate was higher than that in control group （ P 〈 0.05 ）. The score of life quality in observation groups were obviously higher than that of control group （ P 〈 0.05 ）. Liver and kidney function in two groups had no significance difference （ P 〉 0.05 ）. Conclusion h is good therapeutic efficacy and high safety for ulcerative colitis by electric -needle with TCM enema.