基于选择性激光烧结聚己内酯多孔支架的制备和表征

The Preparation and Characterization of Porous Scaffolds Based on Poly-ε-caprolactone via Selective Laser Sintering

用选择性激光烧结技术制备聚己内酯(PCL)多孔支架。用傅里叶红外光谱(FTIR)、扫描电子显微镜(SEM)、X射线衍射分析(XRD)对支架进行了表征,同时测定支架的压缩强度和孔隙率,在此基础上利用细胞毒性实验对支架进行了生物相容性评估。结果表明,烧结前后PCL分子结构未发生变化;烧结PCL支架最合适的工艺参数为3~5 W;随着激光功率的增加,PCL支架物相组成并未发生变化,但结晶度降低,孔隙率由(90.98±2.7)%降低至(76.84±1.48)%,压缩强度由(0.23±0.02)MPa提高至(9.03±0.05)MPa。其良好的生物相容性,表明利用选择性激光烧结制备PCL多孔支架在骨组织工程上具有非常好的应用前景。

Poly-ε-caprolactone （PCL） porous scaffolds were fabricated via selective laser sintering. The characteristics of the porous scaffold were investigated by Fourier transform infrared spectroscopy （FTIR）, scanning electron microscopy （SEM）, X-ray diffraction （XRD）, porosity and compressive strength tests. Furtherly the biocompatibility were evaluated by cytotoxicity test. The results show that the molecular structure of PCL does not change before and after sintered and the most suitable laser power of sintering is between 3 and 5 W. With the increase of laser power, the phase composition of the PCL scaffolds does not change, but the crystallinity decreases. At the same time, the porosity reduces from 90. 98% ± 2. 7%to 76. 84%±1.48%, the compression strength increases from （0. 23±0. 02） MPa to （9.03±0. 05） MPa. The PCL porous scaffolds with good biocompatibility have significant potential in bone tissue engineering via selective laser sintering