夫西地酸对新生儿和小婴儿血清胆红素水平的影响

Effect of fusidic acid on bilirubin level in neonates and infants

目的探讨新生儿和小婴儿应用夫西地酸后血清胆红素的变化。方法对2012-2014年青岛市妇女儿童医院应用夫西地酸的半岁以下患儿用药前后的血清胆红素等指标进行回顾性分析,比较用药前后的血清胆红素变化情况。结果所有138例应用夫西地酸治疗的患儿,治疗后均未出现新发黄疸或原有黄疸加重的情况;其中64例用药前后检测了血生化指标,治疗前后白蛋白、丙氨酸转氨酶、天冬氨酸转氨酶等均无显著差异,治疗后的间接胆红素与总胆红素比值(Ibil/Tbil)比用药前下降了约8%。结论该系列应用夫西地酸的患儿中未见该药对血清胆红素水平的明显影响。

Objective To examine the change of bilirubin level in neonates and infants after administration of fusidic acid. Methods The data of serum bilirubin, alanine aminotransferasese （ALT）, aspartate aminotransferase （AST） and adverse drug reaction were collected retrospectively in neonates and infants and compared statistically before and after administration of fusidic acid. Results Emerging jaundice or exacerbation of the existing jaundice was not found in all the 138 patients after administration of fusidic acid in this analysis. Biochemical markers were measured before and after use of fusidic acid in 64 of the patients. ALT, AST and albumin did not show significant difference before and after use of fusidic acid. However, the ratio between indirect bilirubin and total bilirubin decreased by about 8% after use of fusidic acid. Conclusions Fusidic acid did not show significant effect on serum bilirubin level in the neonates and infants following fusidie acid treatment.