基于静息态功能磁共振的三叉神经痛患者低频振幅研究

Amplitude low-frequency oscillation abnormalities in trigeminal neuralgia patients

目的:探究三叉神经痛(TN)患者静息状态下全脑范围内的局部功能活动变化。方法 :基于30例TN和20例正常被试静息态功能磁共振数据,运用低频振幅(ALFF)数据分析方法,采用双样本t检验统计比较两组被试低频振幅差异。结果:与正常对照组相比,TN患者在左侧颞下回、左侧梭状回的ALFF值降低,左侧眶内额上回、左侧补充运动脑区增高。结论:ALFF分析揭示了TN患者存在的局部脑区异常活动,这些异常可能与患者对疼痛的认知及情感处理有关。

Objective： To explore the regional spontaneous activity changes in the whole brain of trigeminal neuralgia（TN） patients using resting-state fMRI. Methods： Resting-state fMRI datasets of 30 TN patients and 20 healthy controls were ac- quired. The amplitude low-frequency fluctuation（ALFF） and independent-sample t-test were used to compare the brain activity abnormalities between these two groups. Results： In TN patients, we found decreased ALFF in the left superior temporal gyrus and left fusiform, as well as an increased ALFF in the left frontal med orb and left sup motor area. Conclusion： Our results demonstrated the spontaneous activity change underlying TNP, and these abnormalities may contribute to the cognization and emotion of the pain.