摘要
目的:探究三叉神经痛(TN)患者静息状态下全脑范围内的局部功能活动变化。方法 :基于30例TN和20例正常被试静息态功能磁共振数据,运用低频振幅(ALFF)数据分析方法,采用双样本t检验统计比较两组被试低频振幅差异。结果:与正常对照组相比,TN患者在左侧颞下回、左侧梭状回的ALFF值降低,左侧眶内额上回、左侧补充运动脑区增高。结论:ALFF分析揭示了TN患者存在的局部脑区异常活动,这些异常可能与患者对疼痛的认知及情感处理有关。
Objective: To explore the regional spontaneous activity changes in the whole brain of trigeminal neuralgia(TN) patients using resting-state fMRI. Methods: Resting-state fMRI datasets of 30 TN patients and 20 healthy controls were ac- quired. The amplitude low-frequency fluctuation(ALFF) and independent-sample t-test were used to compare the brain activity abnormalities between these two groups. Results: In TN patients, we found decreased ALFF in the left superior temporal gyrus and left fusiform, as well as an increased ALFF in the left frontal med orb and left sup motor area. Conclusion: Our results demonstrated the spontaneous activity change underlying TNP, and these abnormalities may contribute to the cognization and emotion of the pain.
出处
《中国临床医学影像杂志》
北大核心
2017年第5期318-320,共3页
Journal of China Clinic Medical Imaging
基金
2016年广东省中医药常规科研项目立项资助课题(20161008)
关键词
三叉神经痛
磁共振成像
Trigeminal neuralgia
Magnetic resonance imaging