摘要
目的:观察不同频率电针刺激对大鼠痛情绪的作用。方法:本研究以不同频率电针刺激对痛情绪的作用为研究对象。给大鼠左侧后脚掌注射完全弗氏佐剂(CFA),诱导其产生炎性痛并与环境相匹配,建立条件性位置回避(conditioned place avoidance,CPA)模型,给予大鼠环跳穴(GB30)电针刺激(电流3 mA,波宽0.1 ms,刺激频率2、10、100 Hz),通过条件位置回避装置观察在电针刺激前后痛情绪行为变化。结果:2、10、100 Hz电针刺激均明显反转了大鼠的C-CPA反应,但各刺激频率比较差异均无统计学意义(P>0.05)。结论:不同频率的电针刺激均可缓解痛情绪,且无频率依赖性。
Objctive： To observe the relieve effect of different frequencies electroacupuncture stimulation to pain emotion in rats.Method： In this study, we exploreded the effects of electroacupuncture （ EA ） at various frequencies on the pain emotion.Complete Freund＇s adjuvant （ CFA ） was subcutaneously injected into the left hind- paw to induce the inflammatory pain and match the environment to establish conditioned place avoidance （ C-CPA ） behavioral model, then Huantiao acupoints （ GB30 ） in rats were treated by EA （ current intensity 3 mA, width 0.1 ms, stimulus frequency 2, 10, 100 Hz ）, C-CPA behavioral responses were observed.Result： EA at 2, 10, 100 Hz stimulus frequency were all reversed the C-CPA behavioral responses, but there were no significant differences among them （ P〉0.05 ） .Conclusion ： EA at various stimulation frequencies all can eviate the pain emotion of rats, and there is no frequency dependence.
出处
《中国医学创新》
CAS
2017年第14期1-4,共4页
Medical Innovation of China
基金
国家自然科学基金资助项目(81371254)
关键词
电针
刺激频率
条件位置逃避
痛情绪
Electroacupuncture
Stimulus frequency
Conditioned place avoidance
Pain emotion
