原发性失眠全脑度中心度的改变

Change of Whole Brain Degree in Primary Insomnia

【目的】基于静息态功能磁共振成像技术(fMRI),利用度中心度(DC)分析方法探讨原发性失眠(PI)患者静息态下脑神经网络功能连接的异常属性,找寻原发性失眠相关神经机制的影像学证据。【方法】对59例PI患者及47例年龄、性别、受教育程度均匹配的健康对照组进行静息状态下的功能磁共振成像扫描,经预处理和后处理计算出全脑DC值图,采用双样本t检验进行组间比较,分别检测PI组与NC组间DC分布图间的统计学差异。【结果】对比正常对照组,PI患者DC值明显降低的脑区主要包括双侧额中回(MFG)、双侧前扣带回(ACG)及右侧脑岛(Insula)等区域。DC值明显增加的脑区主要包括右侧颞叶中回(MTG)及左侧楔叶(CUN)等脑区(P<0.05)。【结论】基于静息态功能MRI数据的DC分析观察到PI患者在脑区间功能连接改变,DC作为一种新的基于体素水平描述脑网络属性的方法,可能对理解PI神经机制及观察其脑网络属性的改变提供了一个新视角。

[ Objective ] Based on the resting state functional magnetic resonance imaging to investigate the abnormal features of the functional connectivity of resting brain neural network in the patients with primary insomnia, by using voxel-wise whole-brain functional networks analysis of degree centrality （DC） for imaging evidence of neural mechanisms underlying primary insomnia. [ Methods ] The resting state fMRI were performed in 59 PI patients and 47 age, education, and sex- matched normal healthy subjects. Analysis of DC map changes between the two patient groups and the control group were performed by two sample t test. （threshold at P 〈 0.05）. [ Results ] Compared with the control group, the patients with PI showed significantly reduced DC value in bilateral medial frontal gyrus （MFG） , bilateral anterior cingulate gyrus （ACG） , and right insula; and increased DC value in right middle temporal gyrus （MTG）, and left cuneus, （CUN）, P 〈 0.05. [Conclusion]Changes of DC value occurred in some region of brain in the PI patient groups when compared with the control group. It was indicated that DC, as a novel resting-state fMR1 parameter in the voxel-wise whole-brain functional networks, might be an appealing alternative approach for further study on pathologic and neuropsychological states of PI.