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载脂蛋白A1和载脂蛋白B100在冠脉病变进展中的作用 被引量:10

Effects of APOA1 and APOB100 on Progression of Coronary Artery Lesion
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摘要 【目的】通过回顾性资料,分析载脂蛋白(APO)A1、B100对冠状动脉病变进展的影响及预测作用。【方法】入选2010年6月至2015年10月于中山大学附属第三医院行冠状动脉造影或冠脉CTA检查,并在间隔≥6个月后复查冠脉情况的患者(245例),分为冠脉病变非进展组(114例)、进展组(131例)。比较两组间临床资料及生化指标差异,并通过回归分析,了解APOA1、APOB100与冠脉病变进展的关系。【结果】两组比较,冠脉病变非进展组基线APOA1水平(1.33±0.29 vs 1.24±0.25,P=0.015)、APOA1/AOPB100(1.56±0.65 va 1.38±0.44,P=0.014)更高;两组基线AOPB100水平(0.96±0.37 vs 0.97±0.31,P=0.87)无差异。两组随访APOA1水平均较基线水平均升高,冠脉病变进展组APOA1水平变化有统计学意义(1.24±0.25 vs 1.31±0.28,P=0.006)。通过单因素回归分析,基线APOA1、APOA1/APOB100水平与冠脉病变进展负相关;通过多因素回归分析,APOA1(OR=0.245,P=0.005)与冠脉病变进展负相关。【结论】APOA1水平与冠脉病变负相关,可能具有延缓冠脉病变进展作用,且可能有利于预测冠脉病变进展风险。 [ Objective ] The retrospective study was designed to analyze the dynamic relationship between the Apolipoprotein A 1, B100 and the progression of coronary artery lesion. [Methods] Patients who underwent the second coronary angiography or coronary 320-slice CTA at a minimum review interval of 6 months after their first examinations in the Third Affiliated Hospital of Sun Yat-sen University from 2010 to 2015(n = 245) ,were divided into non progress group(n = 114) and progress group(n = 131). We compared the differences of clinical and Biochemical data between two groups, and tried to find out the relationship by Logistic Regression analysis. [Results] The baseline levels of APOA1 (1.33 ± 0.29 vs 1.24 ± 0.25, P = 0.015), APOAI/AOPB100( 1.56 ± 0.65 vs 1.38 ± 0.44, P = 0.014)in non progress group were higher than those in progress group. The baseline levels of APOB 100 were similar in both groups. The follow-up levels of APOA 1 were higher than the baseline levels in both groups, the variation was significant in progress group (1.24 ± 0.25 vs 1.31 ± 0.28, P = 0.006). The levels of APOA1 and APOA1/APOB100 were eorrelated with progression of coronary artery lesion negatively in single-variate logistic regression analysis. The level of APOA 1 ( OR = 0.245, P = 0.005 ) was correlated with progression of coronary artery lesion negatively in multivariate logistic regression analysis. [ Conclusions ] APOA1 may has the effect of delaying the progression of coronary artery lesion, and may predict the progression of coronary artery lesion.
出处 《中山大学学报(医学科学版)》 CAS CSCD 北大核心 2017年第3期395-400,共6页 Journal of Sun Yat-Sen University:Medical Sciences
基金 广东省科技计划项目(2009B030801146)
关键词 载脂蛋白A1 载脂蛋白B100 冠脉病变进展 APOA1 APOB100 progression of coronary artery lesion
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