芪楂口服液药渣对断奶仔猪生长性能和肠道健康的影响

Effects of Qi-Zha Oral Solution Residues on Growth Performance and Intestinal Health of Weaned Piglets

为了探讨中药渣作为饲料原料或饲料添加剂的可行性,本试验选用21日龄断奶仔猪120头,随机分为对照组、芪楂口服液药渣组、发酵芪楂口服液药渣组和氧化锌组,比较研究发酵前和发酵后芪楂口服液药渣对断奶仔猪生长性能、营养物质消化率、肠黏膜形态结构和紧密连接蛋白mRNA相对表达量。每组5个重复,每个重复6头仔猪。试验期为28 d。结果表明:1)试验全期(第1~28天),发酵芪楂口服液药渣组仔猪的料重比低于对照组和芪楂口服液药渣组(P>0.05),氧化锌组仔猪腹泻率显著低于其他各组(P<0.05)。2)试验第28天,发酵芪楂口服液药渣组仔猪的干物质、粗脂肪和粗蛋白质消化率显著低于对照组(P<0.05),粗脂肪消化率显著低于芪楂口服液药渣组(P<0.05),粗蛋白质消化率显著低于氧化锌组(P<0.05)。3)发酵芪楂口服液药渣组仔猪空肠、回肠绒毛高度和绒毛高度/隐窝深度值大于芪楂口服液药渣组(P>0.05),绒毛宽度和隐窝深度小于芪楂口服液药渣组(P>0.05)。4)各组空肠、回肠和结肠闭锁蛋白和紧密连接相关蛋白-1的mRNA相对表达量无显著差异(P>0.05)。综上所述,与芪楂口服液药渣相比,发酵芪楂口服液药渣可在一定程度上改善断奶仔猪肠道形态结构,二者对紧密连接蛋白mRNA相对表达量没有显著影响。

To evaluate the possibility of herbal residues used as feedstuff or feed additive, a total of 120 piglets weaned at 21 days of age were randomly assigned to four groups, representing control group, Qi-Zha oral solution residues （QOR） group, fermented QOR group and zinc oxide group, the effects of QOR and fermented QOR on growth performance, nutrient digestibility, intestinal mucosal morphology and tight junction protein mRNA relative expression of weaned piglets were determined. Each group contained five replicates and each replicate contained six weaned piglets. The experiment lasted for 28 days. The results showed as follows： 1） during the whole experiment stage （day 1 to 28）, the ratio of fee to gain （F/G） of piglets in fermented QOR group was lower than that in control group and QOR group （P〉0.05）; the diarrhea rate of piglets in zinc oxide group was significantly lower than that in other groups （P〈0.05）. 2） At day 28 of the experiment, the digestibility of dry matter （DM）, ether extract （EE） and crude protein （CP） of piglets in fermented QOR group was significantly lower than that in control group （P〈0.05）, the EE digestibility was significantly lower than that in QOR group （P〈0.05）, and the CP digestibility was significantly lower than that in zinc oxide group （P〈0.05）. 3） The villus height and villus height to crypt depth （V/C） value in jejunum and ileum of piglets in fermented QOR group were higher than those in QOR group （P〉0.05）, and the crypt depth and villus width were lower those that in QOR group （P〉0.05）. 4） There were no significant differences on the mRNA relative expression of Occludin and zonula occluden 1 in jejunum, ileum and colon among all groups （P〉0.05）. In conclusion, compared with the QOR, the fermented QOR can improve the intestinal morphology of weaned piglets in a certain extent, there is no significant effect on the mRNA relative expression of tight junction protein when dietary supplementation with fermented QOR and QOR.