叔丁基亚磺酰胺在手性胺类药物合成中的应用

Applications of tert-Butanesulfinamide in the Synthesis of Chiral Amine Drugs

基于手性辅剂诱导的手性胺类药物的不对称合成一直受到研究人员的广泛关注,叔丁基亚磺酰胺是近年发展起来的一种新型手性辅剂,本文综述其近几年在手性胺类药物合成中的应用情况,这对于利用叔丁基亚磺酰胺辅助诱导合成手性胺类化合物具有重要意义,验证了手性辅剂在手性药物合成中的重要作用,为进一步开发新型手性辅剂以及在不对称合成中的应用提供参考。

Asymmetric synthesis of chiral amine drugs based on chiral auxiliary has been extensively concerned by the scientists, tert-butanesulfinamide is a new type of chiral auxiliary developed in recent years. This review describes the applications of tert-butanesulfinamide in the synthesis of chiral amine drugs in recent years, this is significant for the synthesis of chiral amine compounds using tert-butanesulfinamide. And it confirmed that chiral auxiliaries played an important role in asymmetric synthesis of chiral drugs which would be a reference to further development of novel chiral auxiliary and its application in asymmetric synthesis.