睡眠呼吸障碍儿童气道炎症的初步研究

Airway inflammation in sleep disordered breathing children:preliminary results

目的:探讨鼻呼出气一氧化氮值(NNO)对睡眠呼吸障碍(SDB)儿童诊断的临床意义,评估SDB儿童气道炎症的严重程度。方法:选取SDB患儿30例、健康儿童20例为研究对象,用瑞典NIOX MINO仪器无创检测受试者的NNO值。以SPSS 20.0统计软件进行数据分析。结果:与健康儿童相比,SDB患儿的NNO值升高,差异有统计学意义(Z=-2.215,P<0.05)。在SDB患儿中,NNO值与其AHI值呈正相关(r=0.429,P<0.05),与夜间最低血氧值呈负相关(r=-0.482,P<0.01),与其他睡眠参数无相关性。结论:NNO值是反映SDB患儿气道炎症严重程度的潜在指标。

Objective：To assess the clinical significance of nasal nitric oxide（NNO）levels in children with sleep disordered breathing（SDB）.Method：Thirty children with SDB and twenty healthy children were enrolled.The NNO levels were measured non-invasively using a NIOX MINO system.SPSS statistics 20.0 oftware was used to analyze the data.Result：Compared to healthy children,NNO level was significant higher in children with SDB（Z=-2.215,P〈0.05）.Correlation analysis showed that SDB children＇s NNO level was directly correlated with AHI（r=0.429,P〈0.05）,and it was inversely correlated with nadir SaO2（r=-0.482,P〈0.01）.But NNO level was not significantly correlated with other polysomnographic parameters.Conclusion：Our data suggested that NNO levels might be useful for evaluating the disease severity in SDB children.