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替莫唑胺联合全脑放疗和单纯全脑放疗治疗恶性肿瘤脑转移的疗效 被引量:3

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摘要 对替莫唑胺联合全脑放疗和单纯全脑放疗治疗恶性肿瘤脑转移的疗效进行比较和分析。选取收治的86例恶性肿瘤脑转移患者,使用随机数字表法均分为观察组和对照组,观察组接受替莫唑胺联合全脑放疗治疗,对照组仅接受单纯全脑放疗,比较两组是临床疗效。两组在胃肠道反应、血液系统毒性等不良反应发生情况方面无显著差异(P<0.05);观察组近期治疗总有效率显著高于对照组(72.09%vs 41.86%,P<0.05)。相较于单纯全脑放疗,替莫唑胺联合全脑放疗治疗恶性肿瘤脑转移疗效更显著,可显著提高近期治疗有效率,同时不会增加不良反应发生率。
出处 《现代诊断与治疗》 CAS 2017年第1期87-88,共2页 Modern Diagnosis and Treatment
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  • 1石安辉,朱广迎,余荣,马惠民,刘长青,苏星,孙艳,蔡勇,徐晓娜,张珊文,徐博.非小细胞肺癌伴脑转移放疗疗效分析[J].中华肿瘤杂志,2007,29(7):545-548. 被引量:15
  • 2孙燕,石远凯.临床肿瘤内科手册[M].第5版.北京:人民卫生出版社,2010:770.
  • 3CORTOT A B, GEFINI L, ROBINET G, et al. PhaseⅡ trial of temo- zolomide and cisplatin followed by whole brain radiotherapy in non - small - cell lung cancer patients with brain metastases : a GLOT - GF- PC study[J]. Ann Oncol, 2006, 17(9): 1412-1417.
  • 4EBERT B I, NIEMIERKO E, SHAFFER K, et al. Use of temozo- lomide with Other cytotoxic chemotherapy in the treatment of pa- tients with recurrent brain metastases from lung cancer[J]. Oncol- ogist, 2003, 8 ( 1 ) : 69 - 71.
  • 5VAN RIJN J, HEIMANS J J, VAN DEN BERG J, et al. Survival of human glioma ceils treated with various combination of temozolo- mide and x - rays [ J]. Int J Radiat Oncol Biol Phys, 2004, 47 (3) : 779 - 784.
  • 6ADDEO R, DE ROSA C, FAIOLA V, et al. Phase 2 trial of te- mozolomide using protracted low - dose and whole - brain radio- therapy for nonsmall cell lung cancer and breast cancer patients with brain metastases[ J]. Cancer, 2008, 113 (9) : 2524 - 2531.
  • 7Xu YP,Ma SL.The current therapy in patients of non-small cell lung cancerwith brain metastases.Chin J Lung Cancer,2007,10:259-262.
  • 8Schueller P,Schroeder J,Micke O,et al.9 years tumor free survival aft er resection,intraoperative radiotherapy (IORT) and whole brain radiotherapyof a solitary brain metastasis of non-small cell lung cancer.Acta Oncol,2006,45:224-225.
  • 9Rades D,Raabe A,Bajrovic A,et al.Treatment of solitary brain metastasis.Resection followed by whole brain radiation therapy (WBRT) and a radiation boost to the metastatic site.Strahlenther Onkol,2004,180:144-147.
  • 10Westeel V,Bajard A,Jacoulet P,et al.Risk of brain metastases in nonmetastatic non-small cell lung cancer.Lung Cancer,2003,41(Supp12):21.

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