慢性阻塞性肺疾病血清铁代谢与慢性气道炎症的关系研究

Study on the relationship between serum iron metabolism and chronic airway inflammation

目的探讨慢性阻塞性肺疾病(COPD)患者血清铁代谢与慢性气道炎症的关系。方法选取20例慢性阻塞性肺疾病急性加重期(AECOPD)患者的血清,测定血清铁、未饱和铁结合力、转铁蛋白、总铁结合力、铁蛋白、白介素8、TNF-α及肺功能,并与20例正常人对比。结果与正常人比较,AECOPD患者总铁结合力、转铁蛋白均明显降低(P<0.01),而铁蛋白、白介素8、TNF-α明显增高(P<0.05),且肺功能的损害程度与白介素8及TNF-α的水平呈正相关。结论本研究表明AECOPD患者存在铁代谢障碍及慢性气道炎症,对判断病情及预后具有重要的参考价值。

Objective To investigate the relationship between serum iron metabolism and chronic airway inflammation in patients with COPD.Methods Choose Serum of 20 patients with acute exacerbation of chronic obstructive pulmonary disease,Test of serum iron and unsaturated iron binding capacity,total iron binding capacity,transferrin,ferritin,interleukin 8,TNF-αand pulmonary function,and 20 cases of normal controls.The data were analyzed by SPSS 19 statistical software.The variance analysis and T test were used to compare the differences between P〈0.05.Results AECOPD patients compared with healthy controls,AECOPD patients TIBC and transferrin were significantly decreased（P〈0.01）,and ferritin were significantly increased in patients with AECOPD（P〈0.01）,interleukin 8,TNF-αis in normal people was significantly higher（P〈0.05）,and the pulmonary function damage degree positively and white interleukin 8 and TNF-αrelated.Conclusion This study shows that AECOPD patients have iron metabolism disorders and chronic airway inflammation,which has important reference value for judging the disease and prognosis.