摘要
目的探讨2型糖尿病(T2DM)患者血清低密度脂蛋白胆固醇(LDL-C)、胱抑素C(Cys C)与动脉粥样硬化(AS)的相关性。方法选择2014年6月—2016年6月我院内分泌科住院的T2DM患者228例,根据颈动脉内膜中膜厚度(IMT)分为非AS组(n=79)和AS组(n=149),对AS的相关危险因素进行分析。结果单因素分析示,非AS组和AS组2组间LDL-C、Cys C、总胆固醇(TC)、甘油三脂(TG)、年龄、收缩压间差异有统计学意义(P<0.05);多因素Logistic回归分析示,LDL-C、Cys C、年龄及收缩压是T2DM并AS的独立危险因素(P<0.05)。结论 LDL-C与Cys C水平是T2DM并AS的独立危险因素。
Objective To observe the relationship between levels of low density lipoprotein cholesterol（LDL-C）,Cystatin C（Cys C）and Atherosclerosis（AS）in patients with type 2 diabetes mellitus（T2DM）.Methods 228 cases with T_2DM were selected to the endocrinology department of our hospital from June 2014 to June 2016. According to the carotid intima-media thickness（IMT）,patients were divided into two groups：non-AS group（n=79）and AS group（n=149）.A multi-factor Logistic regression was performed to analyze the risk factors associated with the incidence of T_2DM complicated with AS.Results（1）Univariate analysis showed that the incidence of AS was associated with Cys C,LDL-C,TC,TG,age,systolic blood pressure（P〈0.05）;（2）Multi-factor Logistic regression indicated that LDL-C,Cys C,systolic blood pressure and age were the independent risk factors for the incidence of AS（P〈0.05）.Conclusions It is proved that LDL-C and Cys C are the independent risk factors for the incidence of AS with T_2DM.
出处
《基层医学论坛》
2017年第14期1812-1814,共3页
The Medical Forum
